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Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement
dc.creator | Tsiamas, P. | en |
dc.creator | Liu, B. | en |
dc.creator | Cifter, F. | en |
dc.creator | Ngwa, W. F. | en |
dc.creator | Berbeco, R. I. | en |
dc.creator | Kappas, C. | en |
dc.creator | Theodorou, K. | en |
dc.creator | Marcus, K. | en |
dc.creator | Makrigiorgos, M. G. | en |
dc.creator | Sajo, E. | en |
dc.creator | Zygmanski, P. | en |
dc.date.accessioned | 2015-11-23T10:51:17Z | |
dc.date.available | 2015-11-23T10:51:17Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1088/0031-9155/58/3/451 | |
dc.identifier.issn | 0031-9155 | |
dc.identifier.uri | http://hdl.handle.net/11615/33876 | |
dc.description.abstract | This study determines the optimal clinical scenarios for gold nanoparticle dose enhancement as a function of irradiation conditions and potential biological targets using megavoltage x-ray beams. Four hundred and eighty clinical beams were studied for different potential cellular or sub-cellular targets. Beam quality was determined based on a 6 MV linac with and without a flattening filter for various delivery conditions. Dose enhancement ratios DER = D-GNP/D-water were calculated for all cases using the GEANT4 Monte Carlo code and the CEPXS/ONEDANT radiation transport deterministic code. Dose enhancement using GEANT4 agreed with CEPXS/ONEDANT. DER for unflattened beams is similar to 2 times larger than for flattened beams. The maximum DER values were calculated for split-IMRT fields (similar to 6) and for out-of-field areas of an unflattened linac (similar to 17). In-field DER values, at the surface of gold nanoparticles, ranged from 2.2 to 4.2 (flattened beam) and from 3 to 4.7 (unflattened beams). For a GNP cluster with thicknesses of 10 and 100 nm, the DER ranges from 14% to 287%. DER is the greatest for split-IMRT, larger depths, out-of-field areas and/or unflattened linac. Mapping of a GNP location in tumor and normal tissue is essential for efficient and safe delivery of nanoparticle-enhanced radiotherapy. | en |
dc.source | Physics in Medicine and Biology | en |
dc.source.uri | <Go to ISI>://WOS:000313564200006 | |
dc.subject | MONTE-CARLO-SIMULATION | en |
dc.subject | RADIATION-THERAPY | en |
dc.subject | X-RAYS | en |
dc.subject | ENERGY | en |
dc.subject | BRACHYTHERAPY | en |
dc.subject | ELECTRONS | en |
dc.subject | RADIOSENSITIZATION | en |
dc.subject | DNA | en |
dc.subject | Engineering, Biomedical | en |
dc.subject | Radiology, Nuclear Medicine & Medical Imaging | en |
dc.title | Impact of beam quality on megavoltage radiotherapy treatment techniques utilizing gold nanoparticles for dose enhancement | en |
dc.type | journalArticle | en |
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