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The Effect of Plasma Homocysteine Levels on Clinical Outcomes of Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome
dc.creator | Tsangaris, I. | en |
dc.creator | Tsantes, A. | en |
dc.creator | Bagos, P. | en |
dc.creator | Nikolopoulos, G. | en |
dc.creator | Kroupis, C. | en |
dc.creator | Kopterides, P. | en |
dc.creator | Dimopoulou, I. | en |
dc.creator | Orfanos, S. | en |
dc.creator | Kardoulaki, A. | en |
dc.creator | Chideriotis, S. | en |
dc.creator | Travlou, A. | en |
dc.creator | Armaganidis, A. | en |
dc.date.accessioned | 2015-11-23T10:50:49Z | |
dc.date.available | 2015-11-23T10:50:49Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0002-9629 | |
dc.identifier.uri | http://hdl.handle.net/11615/33794 | |
dc.description.abstract | Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important pathogenetic and prognostic determinants of mortality in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The objective of the study was to evaluate the effect of plasma homocysteine levels on the outcomes of patients with ALI/ARDS. Methods: Sixty-nine consecutive ventilated patients with ALI/ARDS were studied. Blood samples were drawn within 3 days of clinical recognition of ARDS. Measurement of plasma homocysteine, vitamin B 12, folate, creatinine, protein C and plasminogen-activator inhibitor-1 antigen levels, and genotyping of the methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms were carried out. The primary outcomes were 28- and 90-day mortality, whereas secondary outcomes included nonpulmonary organ failure-free days, liberation from mechanical ventilation up to day 28, and ventilator-free days during the 28 days after enrollment. Results: In the multivariable analysis, plasma homocysteine concentration adjusted for age, Acute Physiology and Chronic Health Evaluation II score, methylenetetrahydrofolate reductase C677T and A1298C polymorphisms, and levels of plasminogen-activator inhibitor-1 antigen, protein C, creatinine, vitamin B12, and folate was not found to affect significantly mortality at 28 and 90 days (P = 0.39 and P = 0.83, respectively), days without organ failure besides lungs (P = 0.38), the probability of being free from mechanical ventilation at day 28 (P = 0.63), and days without ventilation assistance (P = 0.73). Conclusion: Our data suggest that 'increased plasma homocysteine levels, either alone or in synergy with other thrombophilic risk factors, do not seem to adversely affect the prognosis in patients with ALI/ARDS. | en |
dc.source.uri | <Go to ISI>://WOS:000272811200008 | |
dc.subject | Acute lung injury | en |
dc.subject | Acute respiratory distress syndrome | en |
dc.subject | Plasma | en |
dc.subject | homocysteine | en |
dc.subject | MTHFR C677T polymorphism | en |
dc.subject | MTHFR A1298C polymorphism | en |
dc.subject | PROTEIN-C ACTIVATION | en |
dc.subject | ENDOTHELIAL-CELLS | en |
dc.subject | ATHEROGENIC STIMULUS | en |
dc.subject | VASCULAR-DISEASE | en |
dc.subject | FACTOR-V | en |
dc.subject | COAGULATION | en |
dc.subject | THROMBOMODULIN | en |
dc.subject | ABNORMALITIES | en |
dc.subject | THROMBOSIS | en |
dc.subject | HYPERHOMOCYSTEINEMIA | en |
dc.subject | Medicine, General & Internal | en |
dc.title | The Effect of Plasma Homocysteine Levels on Clinical Outcomes of Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome | en |
dc.type | journalArticle | en |
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