Meta-Analysis Methods
dc.creator | Trikalinos, T. A. | en |
dc.creator | Salanti, G. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Ioannidis, J. P. A. | en |
dc.date.accessioned | 2015-11-23T10:50:24Z | |
dc.date.available | 2015-11-23T10:50:24Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1016/s0065-2660(07)00413-0 | |
dc.identifier.isbn | 978-0-12-373883-7 | |
dc.identifier.issn | 0065-2660 | |
dc.identifier.uri | http://hdl.handle.net/11615/33722 | |
dc.description.abstract | Meta-analysis is the quantitative synthesis of information from several studies. It is applicable to a variety of study designs in genetics, from family-based linkage studies and population-based association studies to genome-wide scans and genome-wide association studies. By combining relevant evidence from many studies, statistical power is increased and more precise estimates may be obtained. Most importantly, meta-analysis provides a framework for the appreciation and assessment of between-study heterogeneity, that is, the methodological, epidemiological, clinical, and biological dissimilarity across the various studies. Being a retrospective research design in most cases, meta-analysis is subject to a variety of selection biases that may undermine its validity. A major challenge is to differentiate genuine between-study heterogeneity from systematic errors and biases. (C) 2008, Elsevier Inc. | en |
dc.source | Genetic Dissection of Complex Traits, 2nd Edition | en |
dc.source.uri | <Go to ISI>://WOS:000280575900015 | |
dc.subject | HARDY-WEINBERG EQUILIBRIUM | en |
dc.subject | GENOME SEARCH METAANALYSIS | en |
dc.subject | GENE-DISEASE | en |
dc.subject | ASSOCIATIONS | en |
dc.subject | QUANTITATIVE-TRAIT LOCI | en |
dc.subject | INDIVIDUAL PATIENT DATA | en |
dc.subject | RANDOMIZED-TRIALS | en |
dc.subject | WIDE ASSOCIATION | en |
dc.subject | COMPLEX DISEASES | en |
dc.subject | LINKAGE ANALYSIS | en |
dc.subject | MYOCARDIAL-INFARCTION | en |
dc.subject | Genetics & Heredity | en |
dc.title | Meta-Analysis Methods | en |
dc.type | bookChapter | en |
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