Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation
dc.creator | Tolia, M. | en |
dc.creator | Tsoukalas, N. | en |
dc.creator | Kyrgias, G. | en |
dc.creator | Mosa, E. | en |
dc.creator | Maras, A. | en |
dc.creator | Kokakis, I. | en |
dc.creator | Liakouli, Z. | en |
dc.creator | Kouvaris, J. R. | en |
dc.creator | Liaskonis, K. | en |
dc.creator | Charalampakis, N. | en |
dc.creator | Pistevou-Gombaki, K. | en |
dc.creator | Kelekis, N. | en |
dc.creator | Kouloulias, V. | en |
dc.date.accessioned | 2015-11-23T10:50:04Z | |
dc.date.available | 2015-11-23T10:50:04Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1155/2015/485732 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | http://hdl.handle.net/11615/33671 | |
dc.description.abstract | Purpose. To identify whether the serum's baseline C-reactive protein (CRP) and albumin (Alb) levels related to clinicopathological parameters and overall survival (OS) in non-small cell lung cancer (NSCLC). Methods. In total, 100 consecutive patients (mean age = 68.38 +/- 10.85 years) that underwent chemoradiotherapy were studied. Measurements of CRP and Alb were performed before any treatment. Results. Serum CRP levels were significantly associated with histological grade (P < 0.001), TNM stage (P < 0.001), PS (P = 0.009), and Alb (P < 0.001). Additionally CRP and Alb levels were found significantly associated with overall survival in univariate analysis (log-rank test, P < 0.001 and P = 0.002, resp.) and CRP remained significant after controlling for age, alcohol, performance status, and TNM stage, whereas albumin showed a borderline effect on the hazard rate (P = 0.052). Conclusions. CRP and Alb are both promising biomarkers in identification of NSCLC patients with poor prognosis and form a possible target for intensifying their therapies. | en |
dc.source.uri | <Go to ISI>://WOS:000359553600001 | |
dc.subject | C-REACTIVE PROTEIN | en |
dc.subject | WEIGHT-LOSS | en |
dc.subject | SURVIVAL | en |
dc.subject | RISK | en |
dc.subject | Biotechnology & Applied Microbiology | en |
dc.subject | Medicine, Research & Experimental | en |
dc.title | Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |