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Association Between the Interleukin-1 beta Gene (IL1B) C-511T Polymorphism and the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Candidate-Gene Association Study
dc.creator | Stefanidis, I. | en |
dc.creator | Kreuer, K. | en |
dc.creator | Dardiotis, E. | en |
dc.creator | Arampatzis, S. | en |
dc.creator | Eleftheriadis, T. | en |
dc.creator | Hadjigeorgiou, G. M. | en |
dc.creator | Zintzaras, E. | en |
dc.creator | Mertens, P. R. | en |
dc.date.accessioned | 2015-11-23T10:48:46Z | |
dc.date.available | 2015-11-23T10:48:46Z | |
dc.date.issued | 2014 | |
dc.identifier | 10.1089/dna.2013.2204 | |
dc.identifier.issn | 1044-5498 | |
dc.identifier.uri | http://hdl.handle.net/11615/33417 | |
dc.description.abstract | Variants of the interleukin-1 beta gene (IL1B) are implicated in the development of diabetic nephropathy (DN). The present candidate-gene association study was conducted to investigate the association between the IL1B C-511T variant and the risk of DN in a Caucasian population. The study population consisted of 173 cases (patients with type 2 diabetes mellitus [DM] and DN) and 186 controls (patients with DM free of DN). Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The PCR product was a 304-bp long DNA fragment of the IL1B gene promoter region, extending from position -702 to -398 and including the polymorphic AvaI site (at position -511). The magnitude of the overall association was tested using the generalized odds ratio (ORG) metric, a genetic model-free approach. The ORs (adjusted for effect modifiers) of the additive and co-dominant models were also estimated. The mode of inheritance was assessed using the degree of dominance index (h). There was a significant difference in the genotype distribution between the group of cases with DN compared with diseased controls free of DN (p = 0.014). Analysis produced a significant ORG (ORG = 1.74, 95% confidence interval [CI] = 1.20-2.52), indicating that the risk of DN is significantly associated with the mutational load. The risk of developing DN is significantly enhanced in IL1B T allele carriers (dominant model, p = 0.005) and in homozygotes (additive model, p = 0.018) respectively. However, the recessive model for T allele (p = 0.097) and the co-dominant model (p = 0.085) produced non-significant results. Considering that the additive model was significant (OR=2.53, 95% CI = 1.20-5.36) and the co-dominant is non-significant (OR=1.53, 95% CI = 0.97-2.40), the mode of inheritance is complete "additiveness," with the degree of dominance being h = 0. The findings provided evidence that the IL1B C-511T variant might be associated with development of DN. | en |
dc.source | DNA and Cell Biology | en |
dc.source.uri | <Go to ISI>://WOS:000338137100008 | |
dc.subject | RECEPTOR ANTAGONIST GENES | en |
dc.subject | KIDNEY-DISEASE | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | METAANALYSIS | en |
dc.subject | MELLITUS | en |
dc.subject | REGION | en |
dc.subject | SECRETION | en |
dc.subject | PROTEIN | en |
dc.subject | CLUSTER | en |
dc.subject | IDDM | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.subject | Cell Biology | en |
dc.subject | Genetics & Heredity | en |
dc.title | Association Between the Interleukin-1 beta Gene (IL1B) C-511T Polymorphism and the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Candidate-Gene Association Study | en |
dc.type | journalArticle | en |
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