Mostrar el registro sencillo del ítem
Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis
dc.creator | Stavropoulos-Kalinoglou, A. | en |
dc.creator | Metsios, G. S. | en |
dc.creator | Panoulas, V. F. | en |
dc.creator | Douglas, K. M. J. | en |
dc.creator | Nevill, A. M. | en |
dc.creator | Jamurtas, A. Z. | en |
dc.creator | Kita, M. | en |
dc.creator | Koutedakis, Y. | en |
dc.creator | Kitas, G. D. | en |
dc.date.accessioned | 2015-11-23T10:48:43Z | |
dc.date.available | 2015-11-23T10:48:43Z | |
dc.date.issued | 2009 | |
dc.identifier | 10.1136/ard.2008.095596 | |
dc.identifier.issn | 0003-4967 | |
dc.identifier.uri | http://hdl.handle.net/11615/33405 | |
dc.description.abstract | Objectives: To assess the association of body mass index (BMI) with modifiable cardiovascular disease (CVD) risk factors in patients with rheumatoid arthritis (RA). Methods: BMI, disease activity, selected CVD risk factors and CVD medication were assessed in 378 (276 women) patients with RA. Patients exceeding accepted thresholds in >= 3 CVD risk factors were classified as having the metabolic syndrome (MetS). Results: BMI independently associated with hypertension (OR = 1.28 (95% CI = 1.22 to 1.34); p = 0.001), high-density lipoprotein (OR = 1.10 (95% CI = 1.06 to 1.15); p = 0.025), insulin resistance (OR = 1.13 (95% CI = 1.08 to 1.18); p = 0.000) and MetS (OR = 1.15 (95% CI = 1.08 to 1.21); p = 0.000). In multivariable analyses, BMI had the strongest associations with CVD risk factors (F(1-354) = 8.663, p = 0.000), and this was followed by lipid-lowering treatment (F(1-354) = 7.651, p = 0.000), age (F(1-354) = 7.541, p = 0.000), antihypertensive treatment (F(1-354) = 4.997, p = 0.000) and gender (F(1-354) = 4.707, p = 0.000). Prevalence of hypertension (p = 0.004), insulin resistance (p = 0.005) and MetS (p = 0.000) was significantly different between patients with RA who were normal, overweight and obese, and BMI differed significantly according to the number of risk factors present (p = 0.000). Conclusions: Increasing BMI associates with increased CVD risk independently of many confounders. RA-specific BMI cut-off points better identify patients with RA at increased CVD risk. Weight-loss regimens should be developed and applied in order to reduce CVD in patients with RA. | en |
dc.source | Annals of the Rheumatic Diseases | en |
dc.source.uri | <Go to ISI>://WOS:000262394000016 | |
dc.subject | HEART-DISEASE | en |
dc.subject | INFLAMMATION | en |
dc.subject | OUTCOMES | en |
dc.subject | WEIGHT | en |
dc.subject | MASS | en |
dc.subject | Rheumatology | en |
dc.title | Associations of obesity with modifiable risk factors for the development of cardiovascular disease in patients with rheumatoid arthritis | en |
dc.type | journalArticle | en |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |