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dc.creatorStagos, D.en
dc.creatorUmstead, T.en
dc.creatorPhelps, D.en
dc.creatorSkaltsounis, L.en
dc.creatorHaroutounian, S.en
dc.creatorFloros, J.en
dc.creatorKouretas, D.en
dc.date.accessioned2015-11-23T10:48:27Z
dc.date.available2015-11-23T10:48:27Z
dc.date.issued2007
dc.identifier10.1080/10715760601064714
dc.identifier.issn10715762
dc.identifier.urihttp://hdl.handle.net/11615/33334
dc.description.abstractSurfactant protein-A (SP-A) is the best studied and most abundant of the protein components of lung surfactant and plays an important role in host defense of the lung. It has been shown that ozone-induced oxidation of SP-A protein changes its functional and biochemical properties. In the present study, eight plant polyphenols (three flavonoids, three hydroxycinnamic acids, and two hydroxybenzoic acids) known as strong antioxidants, were tested for their ability to inhibit ozone-induced SP-A oxidation as a mechanism for chemoprevention against lung damage. SP-A isolated from alveolar proteinosis patients was exposed to ozone (1 ppm) for 4 h. The flavonoids protected SP-A from oxidation in a dose dependent manner. (-)-Epicatechin was the most potent flavonoid and exhibited inhibition of ozone-induced formation of carbonyls by 35% at a concentration as low as 5 μM. Hydroxybenzoic acids inhibited SP-A oxidation in a dose-dependent manner although they were less potent than flavonoids. On the other hand, hydroxycinnamic acids exhibited a different inhibitory pattern. Inhibition was observed only at medium concentrations. The results indicate that inhibition of SP-A oxidation by plant polyphenols may be a mechanism accounting for the protective activity of natural antioxidants against the effects of ozone exposure on lungs.en
dc.sourceFree Radical Researchen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-33947169222&partnerID=40&md5=aee0719ba90c1ebf9feff0f1c9bc157e
dc.subjectLungsen
dc.subjectOzoneen
dc.subjectPlant polyphenolsen
dc.subjectProtein oxidationen
dc.subjectSP-Aen
dc.subjectcaffeic aciden
dc.subjectcarbonyl derivativeen
dc.subjectcatechinen
dc.subjectcoumaric aciden
dc.subjectepicatechinen
dc.subjectferulic aciden
dc.subjectflavonoiden
dc.subjectgallic aciden
dc.subjecthydroxybenzoic aciden
dc.subjectpara coumaric aciden
dc.subjectpolyphenolen
dc.subjectprotocatechuic aciden
dc.subjectrutosideen
dc.subjectsurfactant protein Aen
dc.subjectantioxidant activityen
dc.subjectarticleen
dc.subjectchemoprophylaxisen
dc.subjectcontrolled studyen
dc.subjecthumanen
dc.subjectlung alveolus proteinosisen
dc.subjectlung injuryen
dc.subjectoxidationen
dc.subjectprotein isolationen
dc.subjectAntioxidantsen
dc.subjectFlavonoidsen
dc.subjectHumansen
dc.subjectOxidation-Reductionen
dc.subjectPhenolsen
dc.subjectPlantsen
dc.subjectPulmonary Surfactant-Associated Protein Aen
dc.titleInhibition of ozone-induced SP-A oxidation by plant polyphenolsen
dc.typejournalArticleen


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