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dc.creatorSpanou, C. I.en
dc.creatorVeskoukis, A. S.en
dc.creatorStagos, D.en
dc.creatorLiadaki, K.en
dc.creatorAligiannis, N.en
dc.creatorAngelis, A.en
dc.creatorSkaltsounis, A. L.en
dc.creatorAnastasiadi, M.en
dc.creatorHaroutounian, S. A.en
dc.creatorKouretas, D.en
dc.date.accessioned2015-11-23T10:48:09Z
dc.date.available2015-11-23T10:48:09Z
dc.date.issued2012
dc.identifier10.1007/s13105-011-0117-z
dc.identifier.issn1138-7548
dc.identifier.urihttp://hdl.handle.net/11615/33252
dc.description.abstractLegumes are considered to have beneficial health implications, which have been attributed to their phytochemical content. Polyphenols are considered the most important phytochemical compounds extensively studied for their antioxidant properties. The aim of the present study was to examine the effects of potent antioxidant legume plant extracts on xanthine oxidase (XO), catalase (CAT) and superoxide dismutase (SOD) activities. XO exerts a dual role, as it is the major contributor of free radicals during exercise while it generates uric acid, the most potent antioxidant molecule in plasma. CAT and SOD are two of the main enzymes of the antioxidant defence of tissues. We demonstrate that the majority of the extracts inhibited XO activity, but they had no effect on CAT inhibition and SOD induction when used at low concentrations. These results imply that the tested extracts may be considered as possible source of novel XO inhibitors. However, we have shown that allopurinol administration, a known XO inhibitor, before exercise reduces performance and induces oxidative stress in rats. Considering the fact that the extracts examined had an inhibitory effect on XO activity, possibly posing a restriction in their characterization as antioxidants, phytochemical antioxidant administration before exercise should probably be reconsidered.en
dc.source.uri<Go to ISI>://WOS:000301183600005
dc.subjectAntioxidant enzymesen
dc.subjectXanthine oxidaseen
dc.subjectLegumesen
dc.subjectPlant extractsen
dc.subjectCHRONIC HEART-FAILUREen
dc.subjectOXIDATIVE STRESSen
dc.subjectENDOTHELIAL DYSFUNCTIONen
dc.subjectANTIOXIDANT ACTIVITYen
dc.subjectINHIBITIONen
dc.subjectFLAVONOIDSen
dc.subjectALLOPURINOLen
dc.subjectEXERCISEen
dc.subjectHEALTHen
dc.subjectPOLYPHENOLSen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectPhysiologyen
dc.titleEffects of Greek legume plant extracts on xanthine oxidase, catalase and superoxide dismutase activitiesen
dc.typejournalArticleen


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