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Overexpression of phosphorylated p27(Kip1) at threonine 187 may predict outcome in aggressive B-cell lymphomas
dc.creator | Sirinian, C. | en |
dc.creator | Symeonidis, A. | en |
dc.creator | Giannakoulas, N. | en |
dc.creator | Zolota, V. | en |
dc.creator | Melachrinou, M. | en |
dc.date.accessioned | 2015-11-23T10:47:24Z | |
dc.date.available | 2015-11-23T10:47:24Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.3109/10428194.2011.555026 | |
dc.identifier.issn | 1042-8194 | |
dc.identifier.uri | http://hdl.handle.net/11615/33054 | |
dc.description.abstract | Phosphorylation of p27<SUKip1</SU at threonine 187 (pThr187-p27<SUKip1</SU) occurs frequently in the development of human tumors, directing protein polyubiquitination and subsequent proteasomal degradation. We investigated the immunoexpression of p27<SUKip1</SU and pThr187-p27<SUKip1</SU in 126 B-cell lymphomas and their relation to proliferative activity and clinical parameters. Increased levels of p27<SUKip1</SU and pThr187-p27<SUKip1</SU were significantly correlated with indolent and aggressive lymphomas, respectively (p aEuroS < aEuroS0.001). pThr187-p27<SUKip1</SU expression showed a strong positive correlation with proliferation index in aggressive (p aEuroS== aEuroS0.01) and indolent (p aEuroS < aEuroS0.001) subgroups. Survival analysis revealed that pThr187-p27<SUKip1</SU was an unfavorable prognostic factor for disease-free (p aEuroS== aEuroS0.019) and overall survival (p aEuroS== aEuroS0.003) in aggressive lymphomas. Cox regression analysis demonstrated that the prognostic value of pThr187-p27<SUKip1</SU was independent of the international prognostic index (IPI) score, tumor stage, patient age, and serum lactate dehydrogenase (LDH) level. Overall, our results suggest that high levels of pThr187-p27<SUKip1</SU may predict a worse clinical outcome in patients with aggressive lymphomas.</. | en |
dc.source.uri | <Go to ISI>://WOS:000289686500014 | |
dc.subject | DEPENDENT KINASE INHIBITOR | en |
dc.subject | NON-HODGKINS-LYMPHOMA | en |
dc.subject | SKP2 PROTEIN | en |
dc.subject | EXPRESSION | en |
dc.subject | LIGASE SUBUNIT SKP2 | en |
dc.subject | HUMAN BREAST-CANCER | en |
dc.subject | PROGNOSTIC-SIGNIFICANCE | en |
dc.subject | CYCLIN-E | en |
dc.subject | MALIGNANT-LYMPHOMAS | en |
dc.subject | P27 EXPRESSION | en |
dc.subject | S-PHASE | en |
dc.subject | Oncology | en |
dc.subject | Hematology | en |
dc.title | Overexpression of phosphorylated p27(Kip1) at threonine 187 may predict outcome in aggressive B-cell lymphomas | en |
dc.type | journalArticle | en |
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