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dc.creatorSfyroeras, G. S.en
dc.creatorRoussas, N.en
dc.creatorSaleptsis, V. G.en
dc.creatorArgyriou, C.en
dc.creatorGiannoukas, A. D.en
dc.date.accessioned2015-11-23T10:47:11Z
dc.date.available2015-11-23T10:47:11Z
dc.date.issued2012
dc.identifier10.1016/j.jvs.2011.10.008
dc.identifier.issn0741-5214
dc.identifier.urihttp://hdl.handle.net/11615/32961
dc.description.abstractObjective: Periodontitis is a very common human infection. There is evidence that periodontitis is associated with cerebrovascular disease (CVD) and stroke. The aim of this study is to examine the relationship between periodontal disease and CVD in observational studies. Methods: An electronic search of the English literature using PubMed was conducted. A meta-analysis of the studies reporting on the risk of stroke in patients with periodontitis was performed. Results: Six prospective and seven retrospective studies met the inclusion criteria. Patients with both hemorrhagic and ischemic cerebrovascular events, fatal and nonfatal, were included. Definition of periodontitis was taken directly from included studies. Most studies have been adjusted for common cardiovascular risk factors. Separate statistical analysis was performed for prospective and retrospective studies. Overall adjusted risk of stroke in subjects with periodontitis was 1.47 times higher than in subjects without (95% confidence interval, 1.13-1.92; P = .0035) in prospective and 2.63 times (95% confidence interval, 1.59-4.33; P = .0002) in retrospective studies. The application of the trim and fill algorithm does not change the initial significant inference. Conclusions: There is evidence that periodontitis is associated with increased risk of stroke. However, the results of this meta-analysis should be interpreted with caution because of the heterogeneity of the studies as well as the differences in periodontitis definition. (J Vasc Surg 2012; 55: 1178-84.)en
dc.source.uri<Go to ISI>://WOS:000302145700042
dc.subjectC-REACTIVE PROTEINen
dc.subjectISCHEMIC-STROKEen
dc.subjectTOOTH LOSSen
dc.subjectATHEROSCLEROTICen
dc.subjectPLAQUESen
dc.subjectCARDIOVASCULAR-DISEASEen
dc.subjectRISK-FACTORen
dc.subjectADULTSen
dc.subjectINFECTIONSen
dc.subjectPOPULATIONen
dc.subjectCANCERen
dc.subjectSurgeryen
dc.subjectPeripheral Vascular Diseaseen
dc.titleAssociation between periodontal disease and strokeen
dc.typejournalArticleen


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