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The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations

dc.creatorScholz, S. W.en
dc.creatorXiromerisiou, G.en
dc.creatorFung, H. C.en
dc.creatorEerola, J.en
dc.creatorHellstrom, O.en
dc.creatorPapadimitriou, A.en
dc.creatorHadjigeorgiou, G. M.en
dc.creatorTienari, P. J.en
dc.creatorFernandez, H. H.en
dc.creatorMandel, R.en
dc.creatorOkun, M. S.en
dc.creatorGwinn-Hardy, K.en
dc.creatorSingleton, A. B.en
dc.date.accessioned2015-11-23T10:47:07Z
dc.date.available2015-11-23T10:47:07Z
dc.date.issued2006
dc.identifier10.1016/j.neulet.2005.10.081
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/11615/32935
dc.description.abstractCoexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share common pathogenetic mechanisms. For this reason, we investigated the genotype distribution of the M129V polymorphism of the human prion gene for association with IPD (controls: n = 398, IPD cases: n =400). No association between genotypes in codon 129 and IPD was detected in three distinct Populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD. Published by Elsevier Ireland Ltd.en
dc.sourceNeuroscience Lettersen
dc.source.uri<Go to ISI>://WOS:000235597800011
dc.subjectParkinson's diseaseen
dc.subjectprionen
dc.subjectCreutzfeld-Jakob diseaseen
dc.subjectM129Ven
dc.subjectCREUTZFELDT-JAKOB-DISEASEen
dc.subjectDJ-1 PARK7en
dc.subjectFINNISHen
dc.subjectNeurosciencesen
dc.titleThe human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populationsen
dc.typejournalArticleen


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