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dc.creatorSakkas, L. I.en
dc.creatorSimopoulou, T.en
dc.creatorKatsiari, C.en
dc.creatorBogdanos, D.en
dc.creatorChikanza, I. C.en
dc.date.accessioned2015-11-23T10:46:49Z
dc.date.available2015-11-23T10:46:49Z
dc.date.issued2015
dc.identifier10.1007/s10067-015-2902-5
dc.identifier.issn0770-3198
dc.identifier.urihttp://hdl.handle.net/11615/32803
dc.description.abstractSystemic sclerosis (SSc) is characterized by microvasculopathy (Raynaud's phenomenon and fibrointimal proliferation), presence of autoantibodies and collagen deposition in skin (scleroderma) and internal organs. Microvasculopathy, detected by nailfold capillaroscopy, and disease-specific autoantibodies (anti-topoisomerase I, anti-centromere, anti-RNA polymerase III antibodies) usually appear earlier, even years before scleroderma. At that stage of the disease, immune activation with T cells and B cells promote fibrosis. Diagnosis of SSc has been relied on scleroderma, and by this time, internal organs may have developed fibrosis, a lethal feature with no available treatment. The new EULAR/ACR 2013 criteria for the classification of SSc will help identify SSc patients before fibrosis of internal organs. The early diagnosis of SSc, before the development of fibrosis in internal organs, will allow the introduction of immunosuppressive medications in these patients in a controlled setting (randomized trials). It is anticipated that this approach will change the hitherto grim prognosis of SSc for the better.en
dc.source.uri<Go to ISI>://WOS:000359267100002
dc.subjectClassificationen
dc.subjectCriteriaen
dc.subjectEarly systemic sclerosisen
dc.subjectImmunosuppressionen
dc.subjectTreatmenten
dc.subjectINTERSTITIAL LUNG-DISEASEen
dc.subjectPULMONARY ARTERIAL-HYPERTENSIONen
dc.subjectEULARen
dc.subjectSCLERODERMA TRIALSen
dc.subjectGROWTH-FACTOR RECEPTORen
dc.subjectORGAN INVOLVEMENTen
dc.subjectSTIMULATORY AUTOANTIBODIESen
dc.subjectCLASSIFICATION CRITERIAen
dc.subjectMYCOPHENOLATE-MOFETILen
dc.subjectRAYNAUDS-PHENOMENONen
dc.subjectT-CELLen
dc.subjectRheumatologyen
dc.titleEarly systemic sclerosis-opportunities for treatmenten
dc.typejournalArticleen


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