Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis
dc.creator | Sakkas, L. I. | en |
dc.creator | Chikanza, I. C. | en |
dc.creator | Platsoucas, C. D. | en |
dc.date.accessioned | 2015-11-23T10:46:49Z | |
dc.date.available | 2015-11-23T10:46:49Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1038/ncprheum0346 | |
dc.identifier.issn | 1745-8382 | |
dc.identifier.uri | http://hdl.handle.net/11615/32794 | |
dc.description.abstract | Systemic sclerosis is characterized by extensive fibrosis, microvascular stenosis and autoantibody production. All three characteristics can be accounted for by activation of cells of the immune system. Activation of T cells is antigen-driven and occurs early in the course of the disease, before microscopic evidence of fibrosis. Activated T cells are predominantly of the type 2 T-helper lineage, and produce interleukin-4 and interleukin-13, which induce fibrosis. B cells are also activated early in the course of the disease and, through the production of autoantibodies, cause fibroblasts to adopt a profibrotic phenotype. Macrophages in perivascular infiltrates are activated and produce CC-chemokine ligand 2, transforming growth factor P and platelet derived growth factor, all of which promote fibrosis and fibroproliferation. These new insights have direct impact on the treatment of patients with systemic sclerosis; therapies that target T cells, B cells and their harmful mediators are a logical approach, and preliminary data are promising. | en |
dc.source.uri | <Go to ISI>://WOS:000242238900011 | |
dc.subject | B cells | en |
dc.subject | fibrosis | en |
dc.subject | systemic sclerosis | en |
dc.subject | T cells | en |
dc.subject | vasculopathy | en |
dc.subject | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | en |
dc.subject | GROWTH-FACTOR-BETA | en |
dc.subject | BLOOD | en |
dc.subject | MONONUCLEAR-CELLS | en |
dc.subject | VERSUS-HOST-DISEASE | en |
dc.subject | DNA TOPOISOMERASE-I | en |
dc.subject | T-CELL | en |
dc.subject | MYCOPHENOLATE-MOFETIL | en |
dc.subject | MONOCLONAL-ANTIBODY | en |
dc.subject | DERMAL FIBROBLASTS | en |
dc.subject | ENDOTHELIAL-CELLS | en |
dc.subject | Rheumatology | en |
dc.subject | Social Issues | en |
dc.title | Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis | en |
dc.type | journalArticle | en |
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