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dc.creatorSakkas, G. K.en
dc.creatorGiannaki, C. D.en
dc.creatorKaratzaferi, C.en
dc.creatorMaridaki, M.en
dc.creatorKoutedakis, Y.en
dc.creatorHadjigeorgiou, G. M.en
dc.creatorStefanidis, I.en
dc.date.accessioned2015-11-23T10:46:47Z
dc.date.available2015-11-23T10:46:47Z
dc.date.issued2015
dc.identifier10.1016/j.smrv.2014.07.006
dc.identifier.issn1087-0792
dc.identifier.urihttp://hdl.handle.net/11615/32776
dc.description.abstractRestless legs syndrome (RLS) affects almost one out of three end-stage renal disease patients. This review assesses the current treatment options for uremic RLS and the potential benefits of those treatments on quality of life parameters, cardiovascular mortality and Survival. A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines. Fourteen studies met the inclusion criteria in which the international RLS study group criteria were used as the primary diagnostic tool. Both pharmacological and non-pharmacological approaches were found to reduce the severity of uremic RLS symptoms. Only four studies reported changes on aspects related to quality of life while those changes were also associated with health benefits that resulted in reduced cardiovascular risk. The severity of uremic RLS symptoms can be ameliorated by using dopamine agonists and gabapentin, intravenous iron, exercise or supplementation with vitamins C and E, although some of those treatment benefits may be transient. There is a lack of strong evidence regarding the effects of the pharmacological approaches on quality of life and cardiovascular survival and mortality. In contrast exercise has been proven beneficial in both reducing the RLS symptoms' severity score and improving the quality of life. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.sourceSleep Medicine Reviewsen
dc.source.uri<Go to ISI>://WOS:000354156800005
dc.subjectSleep disordersen
dc.subjectSleepen
dc.subjectEnd-stage renal diseaseen
dc.subjectHemodialysisen
dc.subjectDopamineen
dc.subjectagonistsen
dc.subjectGabapentinen
dc.subjectExercise trainingen
dc.subjectPeriodic limb movementsen
dc.subjectPERIODIC LIMB MOVEMENTSen
dc.subjectSTAGE RENAL-DISEASEen
dc.subjectPLACEBO-CONTROLLED TRIALen
dc.subjectCHRONIC KIDNEY-DISEASEen
dc.subjectVALVULAR HEART-DISEASEen
dc.subjectLONG-TERM TREATMENTen
dc.subjectHEMODIALYSIS-PATIENTSen
dc.subjectDIALYSIS PATIENTSen
dc.subjectDOUBLE-BLINDen
dc.subjectPARKINSONS-DISEASEen
dc.subjectClinical Neurologyen
dc.subjectNeurosciencesen
dc.titleCurrent trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survivalen
dc.typejournalArticleen


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