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Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis
dc.creator | Rigopoulou, E. I. | en |
dc.creator | Davies, E. T. | en |
dc.creator | Bogdanos, D. P. | en |
dc.creator | Liaskos, C. | en |
dc.creator | Mytilinaiou, M. | en |
dc.creator | Koukoulis, G. K. | en |
dc.creator | Dalekos, G. N. | en |
dc.creator | Vergani, D. | en |
dc.date.accessioned | 2015-11-23T10:46:26Z | |
dc.date.available | 2015-11-23T10:46:26Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1111/j.1478-3231.2007.01586.x | |
dc.identifier.issn | 1478-3223 | |
dc.identifier.uri | http://hdl.handle.net/11615/32635 | |
dc.description.abstract | Background/Aims: Primary biliary cirrhosis (PBC) is characterised by the presence of immunoglobulin (Ig) G antimitochondrial antibodies (AMA), which are routinely detected by indirect immunofluorescence (IFL) using composite rodent tissue substrate. The IgG subclass distribution and clinical significance of IFL-detected AMA in patients with PBC have not been previously studied in detail. Methods: We have examined IgG subclass-specific AMA detected by IFL on rodent liver, kidney and stomach tissue substrate using affinity-purified IgG subclass monospecific antisera as revealing reagents in 95 AMA-positive PBC patients from Greece. Results: AMA of any of the IgG1, IgG2 or IgG3 subclasses were present in 89/95 (93.7%) patients. Among those 89, 55 (61.8%) had IgG1, 2, 3 AMA positivity; eight (9%) had IgG1, 2; seven (7.9%) had IgG2, 3; eight ( 9%) had IgG1, 3; nine (10.1%) had IgG1 subclass and two (2.2%) single IgG3 AMA reactivity. IgG4 AMA was absent. IgG3 titres were higher than IgG2 and IgG1 ( P < 0.001) and IgG1 higher than IgG2 (P < 0.001). IgG3 AMA-positive patients had a histologically more advanced disease (P < 0.01) and were more frequently cirrhotic compared with those who were negative (P < 0.01). There was a positive correlation between AMA IgG3 titre and Mayo risk score (r = 0.55, P = 0.009, Spearman's correlation). Conclusions: Our findings suggest that AMA are not restricted to a specific IgG subclass. AMA of the IgG3 subclass are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage. | en |
dc.source.uri | <Go to ISI>://WOS:000249993500009 | |
dc.subject | autoantibody | en |
dc.subject | autoimmune disease | en |
dc.subject | autoimmunity | en |
dc.subject | cholestasis | en |
dc.subject | liver | en |
dc.subject | disease | en |
dc.subject | HEPATITIS-C | en |
dc.subject | AUTOANTIBODIES | en |
dc.subject | PREDOMINANCE | en |
dc.subject | PREVALENCE | en |
dc.subject | ANTI-GP210 | en |
dc.subject | COMPONENT | en |
dc.subject | COMPLEX | en |
dc.subject | COHORT | en |
dc.subject | IGG3 | en |
dc.subject | Gastroenterology & Hepatology | en |
dc.title | Antimitochondrial antibodies of immunoglobulin G3 subclass are associated with a more severe disease course in primary biliary cirrhosis | en |
dc.type | journalArticle | en |
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