Anti-alpha-actinin antibodies cross-react with Anti-ssDNA antibodies in active autoimmune hepatitis
dc.creator | Renaudineau, Y. | en |
dc.creator | Dalekos, G. N. | en |
dc.creator | Gueguen, P. | en |
dc.creator | Zachou, K. | en |
dc.creator | Youinou, P. | en |
dc.date.accessioned | 2015-11-23T10:46:23Z | |
dc.date.available | 2015-11-23T10:46:23Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1007/s12016-007-8050-1 | |
dc.identifier.issn | 1080-0549 | |
dc.identifier.uri | http://hdl.handle.net/11615/32614 | |
dc.description.abstract | Recently, we have observed that the association of anti-F-actin autoantibodies (Abs) with anti-alpha-actinin Abs (double reactivity) was correlated with liver disease activity in autoimmune hepatitis type 1 (AIH-1; Gueguen et al., J Clin Immunol 26:495-505, 2006). As anti-alpha-actinin Abs are also associated with anti-single-stranded (ss) DNA in 16 of 50 (32%) AIH-1 patients, compared with 16 of 401 (4.0%) liver disease control patients, we sought to characterize these Abs in AIH-1. When associated, anti-ssDNA Abs cross-react with anti-alpha-actinin Abs, but neither with anti-double-stranded DNA Abs nor with anti-F-actin Abs. Furthermore, anti-alpha-actinin Abs are associated with high-avidity anti-ssDNA Abs in AIH-1. In addition, double reactivity against alpha-actinin and ssDNA was correlated with clinical and histological activity of the disease and untreated AIH-1 patients. | en |
dc.source.uri | <Go to ISI>://WOS:000256089200007 | |
dc.subject | autoimmune hepatitis type 1 | en |
dc.subject | anti-DNA | en |
dc.subject | anti-alpha-actinin | en |
dc.subject | LUPUS NEPHRITIS | en |
dc.subject | DNA ANTIBODIES | en |
dc.subject | LIVER-DISEASES | en |
dc.subject | AUTOANTIBODIES | en |
dc.subject | TARGET | en |
dc.subject | Allergy | en |
dc.subject | Immunology | en |
dc.title | Anti-alpha-actinin antibodies cross-react with Anti-ssDNA antibodies in active autoimmune hepatitis | en |
dc.type | journalArticle | en |
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