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Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
dc.creator | Pitsikas, N. | en |
dc.creator | Zisopoulou, S. | en |
dc.creator | Sakellaridis, N. | en |
dc.date.accessioned | 2015-11-23T10:45:44Z | |
dc.date.available | 2015-11-23T10:45:44Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1002/jnr.20889 | |
dc.identifier.issn | 0360-4012 | |
dc.identifier.uri | http://hdl.handle.net/11615/32315 | |
dc.description.abstract | There is experimental evidence indicating that the noncompetitive NMDA receptor antagonist MK-801 impairs cognition and produces a series of schizophrenia-like symptoms in rodents (hypermotility, stereotypies, and ataxia). The present study was designed to investigate the efficacy of the nitric oxide (NO) donor molsidomine in counteracting these MK-801-induced behavioral effects in the rat. In a first study, post-training administration of molsidomine (at 4 but not 2 mg/kg) successfully antagonized MK-801-induced performance deficits in a recognition memory test. In a subsequent study, molsidomine (2 and 4 mg/kg) was shown to be unable to reverse MK-801-induced hypermotility but attenuated stereotypies (continuous movement whole cage, body sway, and head weaving) produced by MK-801. Moreover, at 4 mg/kg this NO donor counteracted MK-801-induced ataxia. Our findings indicate that molsidomine attenuates behavioral effects related to the hypofunction of the NMDA receptor suggesting that NO might be involved in the psychotomimetic effects of non-competitive NMDA receptor antagonists. (c) 2006 Wiley-Liss, Inc. | en |
dc.source | Journal of Neuroscience Research | en |
dc.source.uri | <Go to ISI>://WOS:000239456700007 | |
dc.subject | recognition memory | en |
dc.subject | motility | en |
dc.subject | ataxia | en |
dc.subject | stereotypies | en |
dc.subject | LONG-TERM POTENTIATION | en |
dc.subject | SYNTHASE INHIBITOR | en |
dc.subject | OBJECT-RECOGNITION | en |
dc.subject | INDUCED | en |
dc.subject | HYPERLOCOMOTION | en |
dc.subject | PREPULSE INHIBITION | en |
dc.subject | L-ARGININE | en |
dc.subject | L-NAME | en |
dc.subject | PHENCYCLIDINE | en |
dc.subject | MEMORY | en |
dc.subject | RATS | en |
dc.subject | Neurosciences | en |
dc.title | Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801 | en |
dc.type | journalArticle | en |
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