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The 5-HT1A receptor and recognition memory possible modulation of its behavioral effects by the nitrergic system
dc.creator | Pitsikas, N. | en |
dc.creator | Tsitsirigou, S. | en |
dc.creator | Zisopoulou, S. | en |
dc.creator | Sakellaridis, N. | en |
dc.date.accessioned | 2015-11-23T10:45:43Z | |
dc.date.available | 2015-11-23T10:45:43Z | |
dc.date.issued | 2005 | |
dc.identifier | 10.1016/j.bbr.2004.11.007 | |
dc.identifier.issn | 0166-4328 | |
dc.identifier.uri | http://hdl.handle.net/11615/32313 | |
dc.description.abstract | Functional activation of the 5-HT1A receptor inhibits cognition, although discrepant findings have also been reported. The present study was designed to investigate the role of the 5-HT1A receptor on recognition memory in the rat. For this purpose, the effects induced by the 5-HT1A agonist R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT) and the 5-HT1A antagonist WAY 100635 on memory were evaluated by using the object recognition task. In addition, the possible involvement of the nitrergic system on 5-HT1A receptor's effects was also assessed by using the same behavioral procedure. In the first dose-response study, post-training administration of 8-OH-DPAT (0.1 and 0.3 mg/kg, subcutaneously (s.c.)) dose-dependently impaired animals' performance in this test. WAY 100635 (0.3 and 1 mg/kg, intraperitoneally (i.p.)) successfully antagonized these 8-OH-DPAT induced performance deficits. The NO donor molsidomine (2 and 4 mg/kg, i.p.) counteracted cognition deficits produced by the highest dose of 8-OH-DPAT (0.3 mg/kg). Our findings indicate (a) that the 5-HT1A receptor is involved in recognition memory, and (b) that a NO component modulates the effects of the 5-HT1A receptor on learning and memory. (c) 2004 Elsevier B.V. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000228699500011 | |
dc.subject | 8-OH-DPAT | en |
dc.subject | WAY 100635 | en |
dc.subject | 5-HT1A receptor | en |
dc.subject | molsidomine | en |
dc.subject | nitric oxide | en |
dc.subject | object recognition | en |
dc.subject | memory | en |
dc.subject | NITRIC-OXIDE SYNTHASE | en |
dc.subject | LONG-TERM POTENTIATION | en |
dc.subject | OBJECT-RECOGNITION | en |
dc.subject | WORKING-MEMORY | en |
dc.subject | DONOR MOLSIDOMINE | en |
dc.subject | IMPAIRED RATS | en |
dc.subject | RAPHE NUCLEI | en |
dc.subject | WATER | en |
dc.subject | MAZE | en |
dc.subject | IN-VIVO | en |
dc.subject | L-NAME | en |
dc.subject | Behavioral Sciences | en |
dc.subject | Neurosciences | en |
dc.title | The 5-HT1A receptor and recognition memory possible modulation of its behavioral effects by the nitrergic system | en |
dc.type | journalArticle | en |
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