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The nitric oxide donor molsidomine antagonizes age-related memory deficits in the rat

dc.creatorPitsikas, N.en
dc.creatorRigamonti, A. E.en
dc.creatorCella, S. G.en
dc.creatorSakellaridis, N.en
dc.creatorMuller, E. E.en
dc.date.accessioned2015-11-23T10:45:43Z
dc.date.available2015-11-23T10:45:43Z
dc.date.issued2005
dc.identifier10.1016/j.neurobiolaging.2004.04.003
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/11615/32308
dc.description.abstractThe effects of the nitric oxide (NO) donor molsidomine on aged rats' cognition were evaluated in two different behavioral tasks: the step-through passive avoidance paradigm and the object recognition test. Post-training injection of molsidomine (at 4 but not at 2 mg/kg) significantly counteracted the performance deficits displayed by old rats in both the behavioral paradigms. These results support and extend prior findings about the implication of NO in learning and memory mechanisms. In addition, for the first time, a NO donor was found to antagonize age-related memory impairments, suggesting that the integrity of the NO-ergic system may be important in brain aging processes. (C) 2004 Elsevier Inc. All rights reserved.en
dc.sourceNeurobiology of Agingen
dc.source.uri<Go to ISI>://WOS:000226178800010
dc.subjectnitric oxideen
dc.subjectmolsidomineen
dc.subjectagingen
dc.subjectmemoryen
dc.subjectobject recognitionen
dc.subjectpassiveen
dc.subjectavoidanceen
dc.subjectraten
dc.subjectLONG-TERM POTENTIATIONen
dc.subjectOBJECT-RECOGNITIONen
dc.subjectALZHEIMERS-DISEASEen
dc.subjectL-NAMEen
dc.subjectYOUNG-ADULTen
dc.subjectEVANS RATSen
dc.subjectCYCLIC-GMPen
dc.subjectSYNTHASEen
dc.subjectBRAINen
dc.subjectNOen
dc.subjectGeriatrics & Gerontologyen
dc.subjectNeurosciencesen
dc.titleThe nitric oxide donor molsidomine antagonizes age-related memory deficits in the raten
dc.typejournalArticleen


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