Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat
dc.creator | Pitsikas, N. | en |
dc.creator | Rigamonti, A. E. | en |
dc.creator | Bonomo, S. M. | en |
dc.creator | Cella, S. G. | en |
dc.creator | Muller, E. E. | en |
dc.date.accessioned | 2015-11-23T10:45:42Z | |
dc.date.available | 2015-11-23T10:45:42Z | |
dc.date.issued | 2003 | |
dc.identifier | 10.1016/s1043-6618(03)00013-6 | |
dc.identifier.issn | 1043-6618 | |
dc.identifier.uri | http://hdl.handle.net/11615/32305 | |
dc.description.abstract | The present study was designed to investigate the role of nitric oxide (NO) on the acquisition of a recognition memory, task in the rat. For this purpose, the effects on memory exerted by pre-training administration of the NO synthase inhibitor L-NAME (N-omega-nitro-L-arginine methyl ester) and the NO donor molsidomine (N-[ethoxycarbonyl]-3-[4-morpholinosydnomine]) were assessed by using the object recognition task, a working memory paradigm based on the differential exploration of a new and familiar object. In a first dose-response study, it was found that L-NAME (10. 30. and 60 mg kg(-1). i.p.) at 30 but not at 10 mg kg(-1) disrupted animals performance, whereas the dose of 60 mg kg(-1) induced side effects. Molsidomine (2 and 4 mg kg(-1). i.p.) at 4 but not at 2 mg kg(-1), antagonized the L-NAME-induced performance deficits. These results indicate that NO is involved in the acquisition of a recognition memory task. (C) 2003 Elsevier Science Ltd. All rights reserved. | en |
dc.source | Pharmacological Research | en |
dc.source.uri | <Go to ISI>://WOS:000182089300007 | |
dc.subject | nitric oxide | en |
dc.subject | L-NAME | en |
dc.subject | molsidomine | en |
dc.subject | recognition memory | en |
dc.subject | rat | en |
dc.subject | OXIDE SYNTHASE INHIBITOR | en |
dc.subject | NITRIC-OXIDE | en |
dc.subject | OBJECT-RECOGNITION | en |
dc.subject | DONOR | en |
dc.subject | MOLSIDOMINE | en |
dc.subject | IMPAIRMENT | en |
dc.subject | NO | en |
dc.subject | RETENTION | en |
dc.subject | ARGININE | en |
dc.subject | RELEASE | en |
dc.subject | Pharmacology & Pharmacy | en |
dc.title | Molsidomine antagonizes L-NAME-induced acquisition deficits in a recognition memory task in the rat | en |
dc.type | journalArticle | en |
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