Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients
dc.creator | Passam, A. M. | en |
dc.creator | Sourvinos, G. | en |
dc.creator | Krambovitis, E. | en |
dc.creator | Miyakis, S. | en |
dc.creator | Stavrianeas, N. | en |
dc.creator | Zagoreos, I. | en |
dc.creator | Spandidos, D. A. | en |
dc.date.accessioned | 2015-11-23T10:45:11Z | |
dc.date.available | 2015-11-23T10:45:11Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1089/aid.2006.0248 | |
dc.identifier.issn | 0889-2229 | |
dc.identifier.uri | http://hdl.handle.net/11615/32081 | |
dc.description.abstract | The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX(3)CR1-V249I, and CX(3)CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/mu l for patients with baseline CD4 below 200 cells/mu l and above 500 cells/mu l for patients with baseline CD4 between 200 and 500 cells/mu l, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX(3)CR1-249I or CX(3)CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response. | en |
dc.source | Aids Research and Human Retroviruses | en |
dc.source.uri | <Go to ISI>://WOS:000249143200010 | |
dc.subject | HIV-1 DISEASE PROGRESSION | en |
dc.subject | LONG-TERM NONPROGRESSORS | en |
dc.subject | NKT CELL SUBSETS | en |
dc.subject | CEREBROSPINAL-FLUID | en |
dc.subject | INCREASED FREQUENCY | en |
dc.subject | CC-CHEMOKINES | en |
dc.subject | 3'A ALLELES | en |
dc.subject | T-CELLS | en |
dc.subject | INFECTION | en |
dc.subject | INDIVIDUALS | en |
dc.subject | Immunology | en |
dc.subject | Infectious Diseases | en |
dc.subject | Virology | en |
dc.title | Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients | en |
dc.type | journalArticle | en |
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