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DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows
dc.creator | Paraskevopoulou, M. D. | en |
dc.creator | Georgakilas, G. | en |
dc.creator | Kostoulas, N. | en |
dc.creator | Vlachos, I. S. | en |
dc.creator | Vergoulis, T. | en |
dc.creator | Reczko, M. | en |
dc.creator | Filippidis, C. | en |
dc.creator | Dalamagas, T. | en |
dc.creator | Hatzigeorgiou, A. G. | en |
dc.date.accessioned | 2015-11-23T10:44:56Z | |
dc.date.available | 2015-11-23T10:44:56Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1093/nar/gkt393 | |
dc.identifier.issn | 0305-1048 | |
dc.identifier.uri | http://hdl.handle.net/11615/32034 | |
dc.description.abstract | MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression through mRNA degradation and/or translation repression, affecting many biological processes. DIANA-microT web server (http://www.microrna.gr/webServer) is dedicated to miRNA target prediction/functional analysis, and it is being widely used from the scientific community, since its initial launch in 2009. DIANA-microT v5.0, the new version of the microT server, has been significantly enhanced with an improved target prediction algorithm, DIANA-microT-CDS. It has been updated to incorporate miRBase version 18 and Ensembl version 69. The in silico-predicted miRNA-gene interactions in Homo sapiens, Mus musculus, Drosophila melanogaster and Caenorhabditis elegans exceed 11 million in total. The web server was completely redesigned, to host a series of sophisticated workflows, which can be used directly from the on-line web interface, enabling users without the necessary bioinformatics infrastructure to perform advanced multi-step functional miRNA analyses. For instance, one available pipeline performs miRNA target prediction using different thresholds and meta-analysis statistics, followed by pathway enrichment analysis. DIANA-microT web server v5.0 also supports a complete integration with the Taverna Workflow Management System (WMS), using the in-house developed DIANA-Taverna Plug-in. This plug-in provides ready-to-use modules for miRNA target prediction and functional analysis, which can be used to form advanced high-throughput analysis pipelines. | en |
dc.source | Nucleic Acids Research | en |
dc.source.uri | <Go to ISI>://WOS:000323603200027 | |
dc.subject | TARGET PREDICTION | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows | en |
dc.type | journalArticle | en |
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