CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside
dc.creator | Papazisis, K. T. | en |
dc.creator | Geromichalos, G. D. | en |
dc.creator | Kouretas, D. | en |
dc.creator | Dimitriadis, K. A. | en |
dc.creator | Kortsaris, A. H. | en |
dc.date.accessioned | 2015-11-23T10:44:41Z | |
dc.date.available | 2015-11-23T10:44:41Z | |
dc.date.issued | 1999 | |
dc.identifier | 10.1016/s0304-3835(99)00015-4 | |
dc.identifier.issn | 0304-3835 | |
dc.identifier.uri | http://hdl.handle.net/11615/31985 | |
dc.description.abstract | Signal transduction for apoptosis or programmed cell death, after DNA damage in mammalian cells, is believed to involve activation of cyclin-dependent kinases (CDKs), especially CDK-1 (cdc2) and CDK-2. We used CDK-inhibitor olomoucine, a purine analogue to evaluate the role CDK inhibition on cytosine-arabinoside (Ara-C)-induced cell death. The two drugs showed an antagonistic effect, suggesting that apoptosis after exposure to Ara-C is inhibited by olomoucine. DNA-electrophoresis showed a clear inhibition of the apoptotic pattern when olomoucine was added to Ara-C. We conclude that CDK-inhibitor olomoucine inhibits tell death induced by Ara-C. (C) 1999 Published by Elsevier Science Ltd. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000080294300032 | |
dc.subject | apoptosis | en |
dc.subject | olomoucine | en |
dc.subject | CDK | en |
dc.subject | cytosine-arabinoside | en |
dc.subject | CYCLIN-DEPENDENT KINASES | en |
dc.subject | MICHAELIS-MENTEN | en |
dc.subject | KINETIC SYSTEMS | en |
dc.subject | CARCINOMA-CELLS | en |
dc.subject | APOPTOSIS | en |
dc.subject | NEURONS | en |
dc.subject | P21(CIP1/WAF1) | en |
dc.subject | ACTIVATION | en |
dc.subject | CLEAVAGE | en |
dc.subject | CASPASE | en |
dc.subject | Oncology | en |
dc.title | CDK-inhibitor olomoucine inhibits cell death after exposure of cell lines to cytosine-arabinoside | en |
dc.type | journalArticle | en |
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