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ASTRAL Score Predicts 5-Year Dependence and Mortality in Acute Ischemic Stroke
dc.creator | Papavasileiou, V. | en |
dc.creator | Milionis, H. | en |
dc.creator | Michel, P. | en |
dc.creator | Makaritsis, K. | en |
dc.creator | Vemmou, A. | en |
dc.creator | Koroboki, E. | en |
dc.creator | Manios, E. | en |
dc.creator | Vemmos, K. | en |
dc.creator | Ntaios, G. | en |
dc.date.accessioned | 2015-11-23T10:44:38Z | |
dc.date.available | 2015-11-23T10:44:38Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1161/strokeaha.113.001047 | |
dc.identifier.issn | 0039-2499 | |
dc.identifier.uri | http://hdl.handle.net/11615/31974 | |
dc.description.abstract | Background and Purpose-The ASTRAL score was externally validated showing remarkable consistency on 3-month outcome prognosis in patients with acute ischemic stroke. The present study aimed to evaluate ASTRAL score's prognostic accuracy to predict 5-year outcome. Methods-All consecutive patients with acute ischemic stroke registered in the Athens Stroke Registry between January 1, 1998, and December 31, 2010, were included. Patients were excluded if admitted >24 hours after symptom onset or if any ASTRAL score component was missing. End points were 5-year unfavorable functional outcome, defined as modified Rankin Scale 3 to 6, and 5-year mortality. For each outcome, the area under the receiver operating characteristics curve was calculated; also, a multivariate Cox proportional hazards analysis was performed to investigate whether the ASTRAL score was an independent predictor of outcome. The Kaplan-Meier product limit method was used to estimate the probability of 5-year survival for each ASTRAL score quartile. Results-The area under the receiver operating characteristics curve of the score to predict 5-year unfavorable functional outcome was 0.89, 95% confidence interval 0.88 to 0.91. In multivariate Cox proportional hazards analysis, the ASTRAL score was independently associated with 5-year unfavorable functional outcome (hazard ratio, 1.09; 95% confidence interval, 1.08-1.10). The area under the receiver operating characteristics curve for the ASTRAL score's discriminatory power to predict 5-year mortality was 0.81 (95% confidence interval, 0.78-0.83). In multivariate analysis, the ASTRAL score was independently associated with 5-year mortality (hazard ratio, 1.09, 95% confidence interval, 1.08-1.10). During the 5-year follow-up, the probability of survival was significantly lower with increasing ASTRAL score quartiles (log-rank test <0.001). Conclusions-The ASTRAL score reliably predicts 5-year functional outcome and mortality in patients with acute ischemic stroke. | en |
dc.source.uri | <Go to ISI>://WOS:000319465400029 | |
dc.subject | ASTRAL score | en |
dc.subject | functional outcome | en |
dc.subject | modified Rankin Scale | en |
dc.subject | mortality | en |
dc.subject | stroke prognosis | en |
dc.subject | PROGNOSTIC MODELS | en |
dc.subject | EXTERNAL VALIDATION | en |
dc.subject | TELEPHONE | en |
dc.subject | REGISTRY | en |
dc.subject | TRIAL | en |
dc.subject | RISK | en |
dc.subject | Clinical Neurology | en |
dc.subject | Peripheral Vascular Disease | en |
dc.title | ASTRAL Score Predicts 5-Year Dependence and Mortality in Acute Ischemic Stroke | en |
dc.type | journalArticle | en |
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