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dc.creatorPapavasileiou, V.en
dc.creatorMilionis, H.en
dc.creatorMichel, P.en
dc.creatorMakaritsis, K.en
dc.creatorVemmou, A.en
dc.creatorKoroboki, E.en
dc.creatorManios, E.en
dc.creatorVemmos, K.en
dc.creatorNtaios, G.en
dc.date.accessioned2015-11-23T10:44:38Z
dc.date.available2015-11-23T10:44:38Z
dc.date.issued2013
dc.identifier10.1161/strokeaha.113.001047
dc.identifier.issn0039-2499
dc.identifier.urihttp://hdl.handle.net/11615/31974
dc.description.abstractBackground and Purpose-The ASTRAL score was externally validated showing remarkable consistency on 3-month outcome prognosis in patients with acute ischemic stroke. The present study aimed to evaluate ASTRAL score's prognostic accuracy to predict 5-year outcome. Methods-All consecutive patients with acute ischemic stroke registered in the Athens Stroke Registry between January 1, 1998, and December 31, 2010, were included. Patients were excluded if admitted >24 hours after symptom onset or if any ASTRAL score component was missing. End points were 5-year unfavorable functional outcome, defined as modified Rankin Scale 3 to 6, and 5-year mortality. For each outcome, the area under the receiver operating characteristics curve was calculated; also, a multivariate Cox proportional hazards analysis was performed to investigate whether the ASTRAL score was an independent predictor of outcome. The Kaplan-Meier product limit method was used to estimate the probability of 5-year survival for each ASTRAL score quartile. Results-The area under the receiver operating characteristics curve of the score to predict 5-year unfavorable functional outcome was 0.89, 95% confidence interval 0.88 to 0.91. In multivariate Cox proportional hazards analysis, the ASTRAL score was independently associated with 5-year unfavorable functional outcome (hazard ratio, 1.09; 95% confidence interval, 1.08-1.10). The area under the receiver operating characteristics curve for the ASTRAL score's discriminatory power to predict 5-year mortality was 0.81 (95% confidence interval, 0.78-0.83). In multivariate analysis, the ASTRAL score was independently associated with 5-year mortality (hazard ratio, 1.09, 95% confidence interval, 1.08-1.10). During the 5-year follow-up, the probability of survival was significantly lower with increasing ASTRAL score quartiles (log-rank test <0.001). Conclusions-The ASTRAL score reliably predicts 5-year functional outcome and mortality in patients with acute ischemic stroke.en
dc.source.uri<Go to ISI>://WOS:000319465400029
dc.subjectASTRAL scoreen
dc.subjectfunctional outcomeen
dc.subjectmodified Rankin Scaleen
dc.subjectmortalityen
dc.subjectstroke prognosisen
dc.subjectPROGNOSTIC MODELSen
dc.subjectEXTERNAL VALIDATIONen
dc.subjectTELEPHONEen
dc.subjectREGISTRYen
dc.subjectTRIALen
dc.subjectRISKen
dc.subjectClinical Neurologyen
dc.subjectPeripheral Vascular Diseaseen
dc.titleASTRAL Score Predicts 5-Year Dependence and Mortality in Acute Ischemic Strokeen
dc.typejournalArticleen


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