Mostra i principali dati dell'item
Oxidative stress in patients with obstructive sleep apnea syndrome
dc.creator | Ntalapascha, M. | en |
dc.creator | Makris, D. | en |
dc.creator | Kyparos, A. | en |
dc.creator | Tsilioni, I. | en |
dc.creator | Kostikas, K. | en |
dc.creator | Gourgoulianis, K. | en |
dc.creator | Kouretas, D. | en |
dc.creator | Zakynthinos, E. | en |
dc.date.accessioned | 2015-11-23T10:41:33Z | |
dc.date.available | 2015-11-23T10:41:33Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1007/s11325-012-0718-y | |
dc.identifier.issn | 1520-9512 | |
dc.identifier.uri | http://hdl.handle.net/11615/31450 | |
dc.description.abstract | We aimed to investigate whether systemic oxidative stress is increased in patients with obstructive sleep apnea syndrome (OSAS). A total of 18 patients with severe OSAS and 13 controls were included in the study. Inclusion criteria for OSAS patients were: snoring and apnea-hypopnea index (AHI) of > 30 in full polysomnography, no previous treatment for OSAS, non-smoking status, and a medical history of being free of comorbidities known to increase oxidative stress. Controls were recruited among subjects assessed for snoring in the Sleep Laboratory Department if they had AHI < 5. At baseline, patients were evaluated by the Epworth Sleepiness Scale and underwent spirometry, echocardiography, and full polysomnographic study. Blood samples were collected for evaluation of oxidative stress biomarkers [protein carbonyls, reduced (GSH) and oxidized (GSSG) glutathione, 8-isoprostane, thiobarbituric acid-reactive substances (TBARS), catalase activity, Cu-Zn superoxide dysmutase (SOD), total antioxidant capacity (TAC)] before and on the morning following polysomnography. The overnight (morning-night) change (%) of GSH/GSSG ratio and GSH was significantly different between OSAS and controls (p = 0.03 and p = 0.048, respectively). Plasma protein carbonyls, erythrocyte catalase activity, 8-isoprostane, SOD, TBARS, and TAC plasma values were not different between OSAS and controls (p > 0.05). No significant correlation was found between changes in the levels of biomarkers and AHI, arousal, or desaturation index. The present prospective investigation in a population free of comorbidities or factors which may increase systemic oxidative stress provides evidence that obstructive sleep apnea per se might be associated with increased oxidative burden possibly via GSH/GSSG pathway. | en |
dc.source | Sleep and Breathing | en |
dc.source.uri | <Go to ISI>://WOS:000319075800024 | |
dc.subject | Oxidative stress | en |
dc.subject | Obstructive sleep apnea syndrome | en |
dc.subject | Hypoxia-reoxygenation | en |
dc.subject | TBARS | en |
dc.subject | GSH | en |
dc.subject | GSSG | en |
dc.subject | AIRWAY PRESSURE TREATMENT | en |
dc.subject | OXIDIZED GLUTATHIONE | en |
dc.subject | LIPID-PEROXIDATION | en |
dc.subject | BREATH CONDENSATE | en |
dc.subject | KAPPA-B | en |
dc.subject | BLOOD | en |
dc.subject | SUPEROXIDE | en |
dc.subject | THERAPY | en |
dc.subject | DISEASE | en |
dc.subject | HYPERTENSION | en |
dc.subject | Clinical Neurology | en |
dc.subject | Respiratory System | en |
dc.title | Oxidative stress in patients with obstructive sleep apnea syndrome | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |