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dc.creatorNtalapascha, M.en
dc.creatorMakris, D.en
dc.creatorKyparos, A.en
dc.creatorTsilioni, I.en
dc.creatorKostikas, K.en
dc.creatorGourgoulianis, K.en
dc.creatorKouretas, D.en
dc.creatorZakynthinos, E.en
dc.date.accessioned2015-11-23T10:41:33Z
dc.date.available2015-11-23T10:41:33Z
dc.date.issued2013
dc.identifier10.1007/s11325-012-0718-y
dc.identifier.issn1520-9512
dc.identifier.urihttp://hdl.handle.net/11615/31450
dc.description.abstractWe aimed to investigate whether systemic oxidative stress is increased in patients with obstructive sleep apnea syndrome (OSAS). A total of 18 patients with severe OSAS and 13 controls were included in the study. Inclusion criteria for OSAS patients were: snoring and apnea-hypopnea index (AHI) of > 30 in full polysomnography, no previous treatment for OSAS, non-smoking status, and a medical history of being free of comorbidities known to increase oxidative stress. Controls were recruited among subjects assessed for snoring in the Sleep Laboratory Department if they had AHI < 5. At baseline, patients were evaluated by the Epworth Sleepiness Scale and underwent spirometry, echocardiography, and full polysomnographic study. Blood samples were collected for evaluation of oxidative stress biomarkers [protein carbonyls, reduced (GSH) and oxidized (GSSG) glutathione, 8-isoprostane, thiobarbituric acid-reactive substances (TBARS), catalase activity, Cu-Zn superoxide dysmutase (SOD), total antioxidant capacity (TAC)] before and on the morning following polysomnography. The overnight (morning-night) change (%) of GSH/GSSG ratio and GSH was significantly different between OSAS and controls (p = 0.03 and p = 0.048, respectively). Plasma protein carbonyls, erythrocyte catalase activity, 8-isoprostane, SOD, TBARS, and TAC plasma values were not different between OSAS and controls (p > 0.05). No significant correlation was found between changes in the levels of biomarkers and AHI, arousal, or desaturation index. The present prospective investigation in a population free of comorbidities or factors which may increase systemic oxidative stress provides evidence that obstructive sleep apnea per se might be associated with increased oxidative burden possibly via GSH/GSSG pathway.en
dc.sourceSleep and Breathingen
dc.source.uri<Go to ISI>://WOS:000319075800024
dc.subjectOxidative stressen
dc.subjectObstructive sleep apnea syndromeen
dc.subjectHypoxia-reoxygenationen
dc.subjectTBARSen
dc.subjectGSHen
dc.subjectGSSGen
dc.subjectAIRWAY PRESSURE TREATMENTen
dc.subjectOXIDIZED GLUTATHIONEen
dc.subjectLIPID-PEROXIDATIONen
dc.subjectBREATH CONDENSATEen
dc.subjectKAPPA-Ben
dc.subjectBLOODen
dc.subjectSUPEROXIDEen
dc.subjectTHERAPYen
dc.subjectDISEASEen
dc.subjectHYPERTENSIONen
dc.subjectClinical Neurologyen
dc.subjectRespiratory Systemen
dc.titleOxidative stress in patients with obstructive sleep apnea syndromeen
dc.typejournalArticleen


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