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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  •   University of Thessaly Institutional Repository
  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
  • View Item
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Adipokines as mediators of endothelial function and atherosclerosis

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Author
Ntaios, G.; Gatselis, N. K.; Makaritsis, K.; Dalekos, G. N.
Date
2013
DOI
10.1016/j.atherosclerosis.2012.12.029
Keyword
Adipokines
Adiponectin
Leptin
Resistin
CORONARY-HEART-DISEASE
HIGH-MOLECULAR-WEIGHT
ISCHEMIC
CEREBROVASCULAR-DISEASE
PLASMA ADIPONECTIN CONCENTRATION
ACUTE
MYOCARDIAL-INFARCTION
INDEPENDENT RISK-FACTOR
NITRIC-OXIDE SYNTHASE
SMOOTH-MUSCLE-CELL
RHEUMATOID-ARTHRITIS
ADIPOSE-TISSUE
Peripheral Vascular Disease
Metadata display
Abstract
For many decades, adipose tissue was considered as an inactive body compartment that was only used as an energy store. During the recent years, an increasing amount of data has revealed that adipose tissue is a major endocrine and paracrine organ producing numerous enzymes, hormones and growth factors which are collectively termed as adipokines. Several experimental and clinical studies showed that adipokines modulate insulin sensitivity and have an influence on glucose/fat metabolism and obesity. Apart from these properties, recent research revealed several direct actions of adipokines on endothelial function, vascular homeostasis and atherogenesis which are independent of their effects on glucose and fat metabolism. The present review focuses on the direct effects of adipokines on vascular/endothelial function and atherosclerosis and summarizes the experimental and clinical data which suggest a role for these molecules as potential diagnostic and prognostic cardiovascular markers as well as potential therapeutic target to reduce cardiovascular risk. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/11615/31432
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