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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

dc.creatorNalls, M. A.en
dc.creatorPankratz, N.en
dc.creatorLill, C. M.en
dc.creatorDo, C. B.en
dc.creatorHernandez, D. G.en
dc.creatorSaad, M.en
dc.creatorDeStefano, A. L.en
dc.creatorKara, E.en
dc.creatorBras, J.en
dc.creatorSharma, M.en
dc.creatorSchulte, C.en
dc.creatorKeller, M. F.en
dc.creatorArepalli, S.en
dc.creatorLetson, C.en
dc.creatorEdsall, C.en
dc.creatorStefansson, H.en
dc.creatorLiu, X.en
dc.creatorPliner, H.en
dc.creatorLee, J. H.en
dc.creatorCheng, R.en
dc.creatorIkram, M. A.en
dc.creatorIoannidis, J. P. A.en
dc.creatorHadjigeorgiou, G. M.en
dc.creatorBis, J. C.en
dc.creatorMartinez, M.en
dc.creatorPerlmutter, J. S.en
dc.creatorGoate, A.en
dc.creatorMarder, K.en
dc.creatorFiske, B.en
dc.creatorSutherland, M.en
dc.creatorXiromerisiou, G.en
dc.creatorMyers, R. H.en
dc.creatorClark, L. N.en
dc.creatorStefansson, K.en
dc.creatorHardy, J. A.en
dc.creatorHeutink, P.en
dc.creatorChen, H.en
dc.creatorWood, N. W.en
dc.creatorHoulden, H.en
dc.creatorPayami, H.en
dc.creatorBrice, A.en
dc.creatorScott, W. K.en
dc.creatorGasser, T.en
dc.creatorBertram, L.en
dc.creatorEriksson, N.en
dc.creatorForoud, T.en
dc.creatorSingleton, A. B.en
dc.creatorIpdgen
dc.creatorParkins, G. Parkinson's Study Grp PSGen
dc.creatorAndMeen
dc.creatorGenePden
dc.creatorNgrcen
dc.creatorHihgen
dc.creatorAshkenazi Jewish Dataset, Investigaen
dc.creatorChargeen
dc.creatorNabecen
dc.creatorUkbecen
dc.creatorGreek Parkinson's Dis, Consortiumen
dc.creatorAlzheimer Genetic Analysis, Gren
dc.date.accessioned2015-11-23T10:40:28Z
dc.date.available2015-11-23T10:40:28Z
dc.date.issued2014
dc.identifier10.1038/ng.3043
dc.identifier.issn1061-4036
dc.identifier.urihttp://hdl.handle.net/11615/31266
dc.description.abstractWe conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55-4.30; P = 2 x 10(-16)). We also show six risk loci associated with proximal gene expression or DNA methylation.en
dc.sourceNature Geneticsen
dc.source.uri<Go to ISI>://WOS:000341579400013
dc.subjectIMPUTATIONen
dc.subjectVARIANTSen
dc.subjectPOPULATIONen
dc.subjectPREDICTIONen
dc.subjectREGIONen
dc.subjectGENESen
dc.subjectHEARTen
dc.subjectSIZEen
dc.subjectGenetics & Heredityen
dc.titleLarge-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's diseaseen
dc.typejournalArticleen


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