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A new bifunctional tridentate NSN ligand leading to cationic tricarbonyl fac- M(NSN)(CO)(3) (+) (M = Re, Tc-99m) complexes
dc.creator | Mylonas, I. | en |
dc.creator | Triantis, C. | en |
dc.creator | Panagiotopoulou, A. | en |
dc.creator | Patsis, G. | en |
dc.creator | Raptopoulou, C. P. | en |
dc.creator | Terzis, A. | en |
dc.creator | Psycharis, V. | en |
dc.creator | Komiotis, D. | en |
dc.creator | Pelecanou, M. | en |
dc.creator | Pirmettis, I. | en |
dc.creator | Papadopoulos, M. | en |
dc.date.accessioned | 2015-11-23T10:40:18Z | |
dc.date.available | 2015-11-23T10:40:18Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1016/j.ica.2013.02.001 | |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | http://hdl.handle.net/11615/31237 | |
dc.description.abstract | The synthesis and characterization of the new NSN tridentate bifunctional chelating agent 3-[2-(2'-pyridin-2-yl-ethylsulfanyl)ethylamino] propionic acid (as its hydrochloric salt, 1) and of its corresponding rhenium comp lex fac-[Re(NSN)(CO)(3)](+), 2, is described. Both compounds were characterized by elemental analysis, IR and NMR spectroscopies and X-ray crystallography. In complex 2 the coordination geometry around rhenium is distorted octahedral with the NSN atoms participating in the coordination sphere while the carboxylate group remains free. At tracer level, the analogous complex fac-[Tc-99m(NSN)(CO)(3)](+), 3, was obtained in high yield by reacting ligand 1 with the fac-[Tc-99m(H2O)(3)(CO)(3)](+) precursor at pH 6.5. The structure of 3 was established by HPLC comparison to the prototype rhenium comp lex 2. Complex 3 is stable in solution as well as in the presence of strongly coordinating agents like histidine or cysteine. Our data indicate that ligand 1 can be used as a bifunctional NSN chelating agent in the design of potential Tc-99m-radiopharmaceuticals. (C) 2013 Elsevier B.V. All rights reserved. | en |
dc.source | Inorganica Chimica Acta | en |
dc.source.uri | <Go to ISI>://WOS:000318914700002 | |
dc.subject | Rhenium | en |
dc.subject | Technetium | en |
dc.subject | Tricarbonyl complexes | en |
dc.subject | Bifunctional | en |
dc.subject | TECHNETIUM | en |
dc.subject | DERIVATIVES | en |
dc.subject | CORE | en |
dc.subject | BIOMOLECULES | en |
dc.subject | RHENIUM | en |
dc.subject | Chemistry, Inorganic & Nuclear | en |
dc.title | A new bifunctional tridentate NSN ligand leading to cationic tricarbonyl fac- M(NSN)(CO)(3) (+) (M = Re, Tc-99m) complexes | en |
dc.type | journalArticle | en |
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