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Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer
dc.creator | Moulas, A. N. | en |
dc.creator | Gerogianni, I. C. | en |
dc.creator | Papadopoulos, D. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.date.accessioned | 2015-11-23T10:39:57Z | |
dc.date.available | 2015-11-23T10:39:57Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1111/j.1440-1843.2006.00833.x | |
dc.identifier.issn | 1323-7799 | |
dc.identifier.uri | http://hdl.handle.net/11615/31153 | |
dc.description.abstract | Objectives: Epidemiological studies have shown an inverse relationship between dietary vitamin A intake and the risk of developing lung cancer. The aim of this study was to investigate the vitamin A status in patients with lung cancer, by determining the serum levels of retinoic acid, retinol and retinyl palmitate. Methods: In total, 36 patients with lung cancer and 27 controls were assessed. Of the patients 14 had squamous cell carcinoma, 3 adenocarcinoma, 15 non-small cell lung cancer and 4 small cell lung cancer. Serum retinoic acid, retinol and retinyl palmitate levels were determined with HPLC and UV detection, after liquid extraction. Results: Serum retinol levels did not differ between patients (733.5 +/- 326.4 ng/mL) and controls (734.5 +/- 337.1 ng/mL). The retinyl palmitate concentration tended to be lower in patients (14.3 +/- 9.7 ng/mL) than in controls (16.7 +/- 13.7 ng/mL) The serum retinoic acid levels were significantly lower in patients (1.9 +/- 0.6 ng/mL) than in controls (2.5 +/- 1.1 ng/mL, P < 0.05). A positive correlation was observed between the retinol and retinoic acid levels and retinyl palmitate and retinoic acid levels. Conclusions: The lower levels of retinoic acid in patients with lung cancer suggest there may be a deficiency or impairment in retinol metabolism in these patients. Further studies with larger numbers of patients are needed to evaluate the possible relationship between serum retinoid levels and lung cancer. | en |
dc.source.uri | <Go to ISI>://WOS:000235726200006 | |
dc.subject | chemoprevention | en |
dc.subject | lung cancer | en |
dc.subject | retinoic acid | en |
dc.subject | retinoid | en |
dc.subject | vitamin A | en |
dc.subject | VITAMIN-A | en |
dc.subject | BETA-CAROTENE | en |
dc.subject | EFFICACY TRIAL | en |
dc.subject | RISK | en |
dc.subject | CHEMOPREVENTION | en |
dc.subject | PREVENTION | en |
dc.subject | PLASMA | en |
dc.subject | METAPLASIA | en |
dc.subject | TOCOPHEROL | en |
dc.subject | EPITHELIA | en |
dc.subject | Respiratory System | en |
dc.title | Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer | en |
dc.type | journalArticle | en |
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