Association of Syndecan-1 with Angiogenesis-related Markers, Extracellular Matrix Components, and Clinicopathological Features in Colorectal Carcinoma
dc.creator | Mitselou, A. | en |
dc.creator | Skoufi, U. | en |
dc.creator | Tsimogiannis, K. E. | en |
dc.creator | Briasoulis, E. | en |
dc.creator | Vougiouklakis, T. | en |
dc.creator | Arvanitis, D. | en |
dc.creator | Ioachim, E. | en |
dc.date.accessioned | 2015-11-23T10:39:47Z | |
dc.date.available | 2015-11-23T10:39:47Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.uri | http://hdl.handle.net/11615/31085 | |
dc.description.abstract | Syndecan-1 is a transmembrane heparansulfate proteoglycan, which regulates cell proliferation, migration, angiogenesis, cell-to-cell and cell-to-extracellular matrix adhesion and may influence malignant cell behavior. We investigated the alterations of syndecan-1 expression in colorectal cancer and analyzed the relationship between clinicopathological parameters, proliferation indices, angiogenic markers, and extracellular matrix components. Syndecan-1 protein expression observed in the tumorous epithelium was high in 52197 (53.6%) of the studied cases, moderate in 20197 (20.6%), and weak in 5197 (5.22%) of the cases, and there was strong stromal expression in 34.02% of the tumors. Syndecan-1 expression was statistically correlated to VEGF expression in tumor (p=0.001) and vessels (p=0.007). In addition, there was a borderline correlation between syndecan-1 expression and tenascin (p=0.053). Patients with weak staining reaction had a more unfavorable prognosis (p=0.032) in univariate analysis. These results indicate the implication of syndecan-1 in the remodeling and angiogenesis of colorectal cancer tissue, through interaction with other extracellular matrix components and VEGF, probably influencing the tumor progression and aggressiveness. | en |
dc.source | Anticancer Research | en |
dc.source.uri | <Go to ISI>://WOS:000309243200051 | |
dc.subject | Syndecan-1 | en |
dc.subject | extracellular matrix | en |
dc.subject | colorectal cancer | en |
dc.subject | angiogenesis | en |
dc.subject | CELL-SURFACE PROTEOGLYCAN | en |
dc.subject | EPITHELIAL-CELLS | en |
dc.subject | IMMUNOHISTOCHEMICAL | en |
dc.subject | LOCALIZATION | en |
dc.subject | REDUCED EXPRESSION | en |
dc.subject | PROGNOSTIC MARKER | en |
dc.subject | GROWTH-FACTORS | en |
dc.subject | COLON-CANCER | en |
dc.subject | BINDING | en |
dc.subject | FIBRONECTIN | en |
dc.subject | INTERFACE | en |
dc.subject | Oncology | en |
dc.title | Association of Syndecan-1 with Angiogenesis-related Markers, Extracellular Matrix Components, and Clinicopathological Features in Colorectal Carcinoma | en |
dc.type | journalArticle | en |
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