dc.creator | Michalitsi, V. | en |
dc.creator | Dafopoulos, K. | en |
dc.creator | Gourounti, K. | en |
dc.creator | Messini, C. | en |
dc.creator | Ioannou, M. | en |
dc.creator | Christodoulaki, C. | en |
dc.creator | Panagopoulos, P. | en |
dc.creator | Messinis, I. | en |
dc.date.accessioned | 2015-11-23T10:39:35Z | |
dc.date.available | 2015-11-23T10:39:35Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.3109/14767058.2014.921672 | |
dc.identifier.issn | 1476-7058 | |
dc.identifier.uri | http://hdl.handle.net/11615/30996 | |
dc.description.abstract | Objective: To investigate hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in placentae of women with iron-deficiency anemia and beta-thalassemia trait and to correlate the results with hematological parameters as well as with parameters associated with the outcome of pregnancy. Methods: About 126 women who delivered in the Larissa University Hospital were divided in three groups: iron-deficiency anemia (n = 39), beta-thalassemia trait carriers (n = 53) and control group (n = 34). HIF-1 alpha expression was assessed with immunochemical assays and statistical analysis was performed with chi-squared test and ANOVA. Results: HIF-1 alpha immunostaining was intense in the two groups of anemia. A statistically significant association was found between HIF-1 alpha immunoreactivity and hematocrit (p<0.001), hemoglobin (p<0.001), MCV (p<0.001), transferrin (p<0.001) and its receptors (p = 0.040), whereas no significant correlations were observed between HIF-1 alpha, iron serum levels (p = 0.256) and ferritin (p = 0.232). We found no association between HIF-1 alpha and birthweight (p = 0.256), placental weight (p = 0.870) and Apgar score at 1' (p = 0.210) and 5' (p = 0.400). Conclusions: HIF-1 alpha expression is affected by anemia, although this factor has no important direct effect on the perinatal outcome. | en |
dc.source.uri | <Go to ISI>://WOS:000351133400019 | |
dc.subject | Anemia | en |
dc.subject | beta-thalassemia trait | en |
dc.subject | HIF-1 alpha | en |
dc.subject | hypoxia | en |
dc.subject | iron deficiency | en |
dc.subject | anemia | en |
dc.subject | pregnancy | en |
dc.subject | SERUM TRANSFERRIN RECEPTOR | en |
dc.subject | TROPHOBLAST DIFFERENTIATION | en |
dc.subject | PREECLAMPTIC | en |
dc.subject | PLACENTAE | en |
dc.subject | TRANSCRIPTION FACTORS | en |
dc.subject | PREGNANCY | en |
dc.subject | OXYGEN | en |
dc.subject | GROWTH | en |
dc.subject | COMPLEX | en |
dc.subject | HIF | en |
dc.subject | Obstetrics & Gynecology | en |
dc.title | Hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression in placentae of women with iron deficiency anemia and beta-thalassemia trait | en |
dc.type | journalArticle | en |