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Ovarian regulators of gonadotropin secretion
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:39:24Z | |
dc.date.available | 2015-11-23T10:39:24Z | |
dc.date.issued | 2000 | |
dc.identifier.isbn | 1-57331-226-6 | |
dc.identifier.issn | 0077-8923 | |
dc.identifier.uri | http://hdl.handle.net/11615/30920 | |
dc.description.abstract | Great progress in the ovarian mechanisms that control gonadotrophin secretion in women has recently been achieved, Estradiol (E-2) is the main component of the ovarian negative effect on basal gonadotropin secretion during the normal menstrual cycle. However, nonsteroidal substances such as inhibins and activins that can affect follicle stimulating hormone (FSH) secretion in vitro may also participate in the control of FSH secretion in vivo. Recent evidence has shown that the ovaries also produce another nonsteroidal substance, named gonadotropin surge-attenuating factor (GnSAF), that specifically attenuates GnRH-induced LH secretion and the endogenous LH surge in superovulated women. It is possible that during the normal menstrual cycle GnSAF controls the amplitude of the midcycle LH surge by antagonizing the stimulating effect of E-2 on the pituitary. | en |
dc.source | Young Woman at the Rise of the 21st Century: Gynecological and Reproductive Issues in Health and Disease | en |
dc.source.uri | <Go to ISI>://WOS:000087754500003 | |
dc.subject | SURGE-ATTENUATING FACTOR | en |
dc.subject | FOLLICLE-STIMULATING-HORMONE | en |
dc.subject | HUMAN | en |
dc.subject | MENSTRUAL-CYCLE | en |
dc.subject | NORMAL WOMEN | en |
dc.subject | FACTOR GNSAF | en |
dc.subject | SUPEROVULATION INDUCTION | en |
dc.subject | PITUITARY-RESPONSE | en |
dc.subject | INHIBITING FACTOR | en |
dc.subject | DIMERIC INHIBIN | en |
dc.subject | PURIFICATION | en |
dc.subject | Multidisciplinary Sciences | en |
dc.subject | Obstetrics & Gynecology | en |
dc.title | Ovarian regulators of gonadotropin secretion | en |
dc.type | bookChapter | en |
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