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Hemoglobin, erythropoietin and systemic inflammation in exacerbations of chronic obstructive pulmonary disease
dc.creator | Markoulaki, D. | en |
dc.creator | Kostikas, K. | en |
dc.creator | Papatheodorou, G. | en |
dc.creator | Koutsokera, A. | en |
dc.creator | Alchanatis, M. | en |
dc.creator | Bakakos, P. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Roussos, C. | en |
dc.creator | Koulouris, N. G. | en |
dc.creator | Loukides, S. | en |
dc.date.accessioned | 2015-11-23T10:38:59Z | |
dc.date.available | 2015-11-23T10:38:59Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1016/j.ejim.2010.07.010 | |
dc.identifier.issn | 0953-6205 | |
dc.identifier.uri | http://hdl.handle.net/11615/30747 | |
dc.description.abstract | Background: Systemic inflammation may represent a possible cause of anemia. Previous data support that anemic patients with COPD present high erythropoietin (EPO) levels, suggestive of EPO resistance, possibly mediated through inflammatory mechanisms. Objectives: We aimed to determine whether systemic inflammation, which is usually up-regulated during exacerbations of COPD (ECOPD) is associated with low hemoglobin levels expressing erythropoietin resistance. Methods: Hemoglobin (Hb), EPO and serum biomarkers of systemic inflammation [CRP, TNF-alpha, fibrinogen and IL-6] were assessed at three time points (admission, resolution and stable phases) in a selected cohort of 93 COPD patients. Results: Hemoglobin levels were significantly lower on admission compared to resolution and stable phases (median 12.1 g/dl [interquartile ranges 11.2-12.7], vs 13.5 [12.4-14.3] vs 13.4 [12.7-14.08], respectively p = 0.002), whereas EPO was significantly higher on admission compared to resolution and stable phases. A negative association between Hb and IL-6 and a positive association between EPO and IL-6 were observed only during the acute phase of exacerbation. EPO and Hb were negatively associated during the acute phase, whereas they were positively associated during discharge and stable phase. Conclusions: In this observational study we have shown that during admission for ECOPD Hb levels are decreased and EPO levels are increased. We have also identified a negative association between Hb and EPO. The above association is mainly related to increased IL-6 levels, indicating a possible EPO resistance through the mechanism of increased systemic inflammatory process. (C) 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000286191400022 | |
dc.subject | Anemia | en |
dc.subject | COPD | en |
dc.subject | Exacerbations | en |
dc.subject | Systemic inflammation | en |
dc.subject | Erythropoietin | en |
dc.subject | RHEUMATOID-ARTHRITIS | en |
dc.subject | ANEMIA | en |
dc.subject | DIAGNOSIS | en |
dc.subject | RECOVERY | en |
dc.subject | THERAPY | en |
dc.subject | IMPACT | en |
dc.subject | Medicine, General & Internal | en |
dc.title | Hemoglobin, erythropoietin and systemic inflammation in exacerbations of chronic obstructive pulmonary disease | en |
dc.type | journalArticle | en |
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