Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human rodent somatic cell hybrid DNA templates
dc.creator | Marcoulatos, P. | en |
dc.creator | Koussidis, G. | en |
dc.creator | Mamuris, Z. | en |
dc.creator | Velissariou, V. | en |
dc.creator | Vamvakopoulos, N. C. | en |
dc.date.accessioned | 2015-11-23T10:38:51Z | |
dc.date.available | 2015-11-23T10:38:51Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 1079-9907 | |
dc.identifier.uri | http://hdl.handle.net/11615/30691 | |
dc.description.abstract | Interleukin-2 (IL-2) is the first lymphokine secreted following T cell activation, Several transcription factors regulate IL-2 gene expression, including the nuclear factor of activated T cells (NFAT), NFAT acts at the antigen receptor response element-2 (ARRE-2) sequence in the IL-2 enhancer and is the nuclear target of T cell stimulation signals and the immunosuppressant drugs cyclosporine and FK506, which are potent inhibitors of IL-2 gene transcription, NFAT has been cloned and found to consist of two subunits, NF45 (ILF2) and NF90 (ILF3), This communication reports the assignment of NF45, interleukin enhancer binding factor 2 gene (ILF2), to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction (PCR) amplification of ILF2-specific DNA sequences from well-characterized human-rodent somatic cell hybrid DNA. | en |
dc.source | Journal of Interferon and Cytokine Research | en |
dc.source.uri | <Go to ISI>://WOS:A1996VZ42300009 | |
dc.subject | HUMAN B-CELLS | en |
dc.subject | CYCLOSPORINE-A | en |
dc.subject | LYMPHOCYTES-T | en |
dc.subject | ACTIVATION GENES | en |
dc.subject | RECEPTOR | en |
dc.subject | EXPRESSION | en |
dc.subject | FK506 | en |
dc.subject | ELEMENTS | en |
dc.subject | PROTEINS | en |
dc.subject | PROMOTER | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.subject | Cell Biology | en |
dc.subject | Immunology | en |
dc.title | Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human rodent somatic cell hybrid DNA templates | en |
dc.type | journalArticle | en |
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