dc.creator | Malli, F. | en |
dc.creator | Bardaka, F. | en |
dc.creator | Tsilioni, I. | en |
dc.creator | Karetsi, E. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Daniil, Z. | en |
dc.date.accessioned | 2015-11-23T10:38:34Z | |
dc.date.available | 2015-11-23T10:38:34Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1016/j.fct.2013.05.016 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.uri | http://hdl.handle.net/11615/30574 | |
dc.description.abstract | Objective and design: Sarcoidosis and idiopathic pulmonary fibrosis (IPF) are both associated with deregulated inflammatory mechanisms partially triggered by aggravated oxidative stress. 8-Isoprostane has been proposed as a reliable marker of oxidative stress, linked to several pulmonary diseases. We aimed to explore differences in 8-isoprostane levels in IPF and sarcoidosis patients, and controls. Methods: We included 16 IPF and 55 sarcoidosis patients, as well as 17 controls in the study. 8-Isoprostane levels were measured in serum and in bronchoalveolar lavage (BAL). Results: Serum 8-isoprostane levels were increased in all patient groups vs controls (p < 0.001). The systemic 8-isoprostane concentrations were higher in sarcoidosis patients as compared to IPF subjects and controls (p = 0.017 and p < 0.001, respectively). IPF patients exhibited increased serum 8-isoprostane levels when compared to controls (p < 0.001). Sarcoidosis patients presented significantly increased 8-isoprostane BAL levels when compared to IPF patients (p = 0.002). Conclusion: Our data indicate that the level of oxidative stress, as reflected by 8-isoprostane concentrations, is enhanced in patients with sarcoidosis, and to a lesser extent, in IPF patients when compared to controls, suggesting a potential implication of redox imbalance in both diseases. (C) 2013 Elsevier Ltd. All rights reserved. | en |
dc.source | Food and Chemical Toxicology | en |
dc.source.uri | <Go to ISI>://WOS:000329000800024 | |
dc.subject | Sarcoidosis | en |
dc.subject | Idiopathic pulmonary fibrosis | en |
dc.subject | Oxidative stress | en |
dc.subject | Isoprostane | en |
dc.subject | OXIDATIVE STRESS | en |
dc.subject | ISOPROSTANES | en |
dc.subject | INFLAMMATION | en |
dc.subject | STATEMENT | en |
dc.subject | RELEASE | en |
dc.subject | DISEASE | en |
dc.subject | CELLS | en |
dc.subject | Food Science & Technology | en |
dc.subject | Toxicology | en |
dc.title | 8-Isoprostane levels in serum and bronchoalveolar lavage in idiopathic pulmonary fibrosis and sarcoidosis | en |
dc.type | journalArticle | en |