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K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma
dc.creator | Lyronis, I. D. | en |
dc.creator | Baritaki, S. | en |
dc.creator | Bizakis, I. | en |
dc.creator | Krambovitis, E. | en |
dc.creator | Spandidos, D. A. | en |
dc.date.accessioned | 2015-11-23T10:38:17Z | |
dc.date.available | 2015-11-23T10:38:17Z | |
dc.date.issued | 2008 | |
dc.identifier | 10.1007/s12253-008-9032-1 | |
dc.identifier.issn | 1219-4956 | |
dc.identifier.uri | http://hdl.handle.net/11615/30465 | |
dc.description.abstract | The Ras/Raf/MEK/ERK (MAPK) signal transduction cascade is an important mediator of a number of cellular fates including growth, survival and apoptosis. The aim of this study was to determine the incidence of B-raf, Kirsten-ras (K-ras) and Neuroblastoma-ras (N-ras) gene mutations in esophageal squamous cell carcinoma (ESCC) in the Greek population. DNA was extracted from 30 ESCC and 32 normal esophageal specimens and screened for V600E B-raf, and K-ras/N-ras codon 12 mutations, by PCR-RFLP based analysis. Among the genes tested, only the heterozygous K-ras mutation was detected in 5 out of the 30 ESCC specimens (16%), whereas no mutation was found in the normal esophageal tissue (P < 0.022). The normal samples were screened negative for N-ras and V600E B-raf mutations. The increased risk of esophageal cancer was correlated with tobacco use (OR=3.5, P < 0.023) and alcohol abuse (OR=7.22, P < 0.001), accompanied with the high incidence of the k-ras codon 12 mutation (22%, OR=1.77 and 21%, OR=1.52), respectively. A similar positive association was seen in human papilloma virus (HPV)-infected patients (OR=5.66, P < 0.003). Our overall findings demonstrate that the mutational activation of the K-ras gene, HPV infection and tobacco or alcohol abuse, can be considered independently or in combination as high risk factors for ESCC development. | en |
dc.source.uri | <Go to ISI>://WOS:000259698300007 | |
dc.subject | esophageal squamous cell carcinoma | en |
dc.subject | human papilloma virus | en |
dc.subject | B-raf | en |
dc.subject | K-ras | en |
dc.subject | N-ras | en |
dc.subject | CELL CARCINOMA | en |
dc.subject | BRAF GENE | en |
dc.subject | B-RAF | en |
dc.subject | CANCER | en |
dc.subject | RISK | en |
dc.subject | ADENOCARCINOMAS | en |
dc.subject | PAPILLOMAVIRUS | en |
dc.subject | NECK | en |
dc.subject | HEAD | en |
dc.subject | Oncology | en |
dc.subject | Pathology | en |
dc.title | K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma | en |
dc.type | journalArticle | en |
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