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The past, present and future in scaffold-based tendon treatments

dc.creatorLomas, A. J.en
dc.creatorRyan, C. N. M.en
dc.creatorSorushanova, A.en
dc.creatorShologu, N.en
dc.creatorSideri, A. I.en
dc.creatorTsioli, V.en
dc.creatorFthenakis, G. C.en
dc.creatorTzora, A.en
dc.creatorSkoufos, I.en
dc.creatorQuinlan, L. R.en
dc.creatorO'Laighin, G.en
dc.creatorMullen, A. M.en
dc.creatorKelly, J. L.en
dc.creatorKearns, S.en
dc.creatorBiggs, M.en
dc.creatorPandit, A.en
dc.creatorZeugolis, D. I.en
dc.date.accessioned2015-11-23T10:38:07Z
dc.date.available2015-11-23T10:38:07Z
dc.date.issued2015
dc.identifier10.1016/j.addr.2014.11.022
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/11615/30391
dc.description.abstractTendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.en
dc.sourceAdvanced Drug Delivery Reviewsen
dc.source.uri<Go to ISI>://WOS:000355710100018
dc.subjectHuman and equine tendon injuryen
dc.subjectTendon cellular and extracellularen
dc.subjectcompositionen
dc.subjectTendon healingen
dc.subjectTissue graftsen
dc.subjectBiomaterialsen
dc.subjectSustained anden
dc.subjectlocalised delivery of therapeutics/biologicsen
dc.subjectANTERIOR CRUCIATE-LIGAMENTen
dc.subjectPLATELET-RICH PLASMAen
dc.subjectMESENCHYMALen
dc.subjectSTEM-CELLSen
dc.subjectDIGITAL FLEXOR TENDONen
dc.subjectTISSUE ENGINEERING APPLICATIONSen
dc.subjectHUMAN ACHILLES-TENDONen
dc.subjectMARROW STROMAL CELLSen
dc.subjectROTATOR CUFF REPAIRen
dc.subjectGROWTH-FACTOR SUPPLEMENTATIONen
dc.subjectPROXIMAL SUSPENSORY DESMITISen
dc.subjectPharmacology & Pharmacyen
dc.titleThe past, present and future in scaffold-based tendon treatmentsen
dc.typejournalArticleen


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