Assessment of gene-by-sex interaction effect on bone mineral density
dc.creator | Liu, C. T. | en |
dc.creator | Estrada, K. | en |
dc.creator | Yerges-Armstrong, L. M. | en |
dc.creator | Amin, N. | en |
dc.creator | Evangelou, E. | en |
dc.creator | Li, G. | en |
dc.creator | Minster, R. L. | en |
dc.creator | Carless, M. A. | en |
dc.creator | Kammerer, C. M. | en |
dc.creator | Oei, L. | en |
dc.creator | Zhou, Y. H. | en |
dc.creator | Alonso, N. | en |
dc.creator | Dailiana, Z. | en |
dc.creator | Eriksson, J. | en |
dc.creator | Garcia-Giralt, N. | en |
dc.creator | Giroux, S. | en |
dc.creator | Husted, L. B. | en |
dc.creator | Khusainova, R. I. | en |
dc.creator | Koromila, T. | en |
dc.creator | Kung, A. W. | en |
dc.creator | Lewis, J. R. | en |
dc.creator | Masi, L. | en |
dc.creator | Mencej-Bedrac, S. | en |
dc.creator | Nogues, X. | en |
dc.creator | Patel, M. S. | en |
dc.creator | Prezelj, J. | en |
dc.creator | Richards, J. B. | en |
dc.creator | Sham, P. C. | en |
dc.creator | Spector, T. | en |
dc.creator | Vandenput, L. | en |
dc.creator | Xiao, S. M. | en |
dc.creator | Zheng, H. F. | en |
dc.creator | Zhu, K. | en |
dc.creator | Balcells, S. | en |
dc.creator | Brandi, M. L. | en |
dc.creator | Frost, M. | en |
dc.creator | Goltzman, D. | en |
dc.creator | Gonzalez-Macias, J. | en |
dc.creator | Karlsson, M. | en |
dc.creator | Khusnutdinova, E. K. | en |
dc.creator | Kollia, P. | en |
dc.creator | Langdahl, B. L. | en |
dc.creator | Ljunggren, O. | en |
dc.creator | Lorentzon, M. | en |
dc.creator | Marc, J. | en |
dc.creator | Mellstroem, D. | en |
dc.creator | Ohlsson, C. | en |
dc.creator | Olmos, J. M. | en |
dc.creator | Ralston, S. H. | en |
dc.creator | Riancho, J. A. | en |
dc.creator | Rousseau, F. | en |
dc.creator | Urreizti, R. | en |
dc.creator | Van Hul, W. | en |
dc.creator | Zarrabeitia, M. T. | en |
dc.creator | Castano-Betancourt, M. | en |
dc.creator | Demissie, S. | en |
dc.creator | Grundberg, E. | en |
dc.creator | Herrera, L. | en |
dc.creator | Kwan, T. | en |
dc.creator | Medina-Gomez, C. | en |
dc.creator | Pastinen, T. | en |
dc.creator | Sigurdsson, G. | en |
dc.creator | Thorleifsson, G. | en |
dc.creator | VanMeurs, J. B. J. | en |
dc.creator | Blangero, J. | en |
dc.creator | Hofman, A. | en |
dc.creator | Liu, Y. M. | en |
dc.creator | Mitchell, B. D. | en |
dc.creator | O'Connell, J. R. | en |
dc.creator | Oostra, B. A. | en |
dc.creator | Rotter, J. I. | en |
dc.creator | Stefansson, K. | en |
dc.creator | Streeten, E. A. | en |
dc.creator | Styrkarsdottir, U. | en |
dc.creator | Thorsteinsdottir, U. | en |
dc.creator | Tylavsky, F. A. | en |
dc.creator | Uitterlinden, A. | en |
dc.creator | Cauley, J. A. | en |
dc.creator | Harris, T. B. | en |
dc.creator | Ioannidis, J. P. A. | en |
dc.creator | Psaty, B. M. | en |
dc.creator | Robbins, J. A. | en |
dc.creator | Zillikens, M. C. | en |
dc.creator | VanDuijn, C. M. | en |
dc.creator | Prince, R. L. | en |
dc.creator | Karasik, D. | en |
dc.creator | Rivadeneira, F. | en |
dc.creator | Kiel, D. P. | en |
dc.creator | Cupples, L. A. | en |
dc.creator | Hsu, Y. H. | en |
dc.date.accessioned | 2015-11-23T10:38:04Z | |
dc.date.available | 2015-11-23T10:38:04Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1002/jbmr.1679 | |
dc.identifier.issn | 0884-0431 | |
dc.identifier.uri | http://hdl.handle.net/11615/30375 | |
dc.description.abstract | Sexual dimorphism in various bone phenotypes, including bone mineral density (BMD), is widely observed; however, the extent to which genes explain these sex differences is unclear. To identify variants with different effects by sex, we examined gene-by-sex autosomal interactions genome-wide, and performed expression quantitative trait loci (eQTL) analysis and bioinformatics network analysis. We conducted an autosomal genome-wide meta-analysis of gene-by-sex interaction on lumbar spine (LS) and femoral neck (FN) BMD in 25,353 individuals from 8 cohorts. In a second stage, we followed up the 12 top single-nucleotide polymorphisms (SNPs; p?<?1?X?10-5) in an additional set of 24,763 individuals. Gene-by-sex interaction and sex-specific effects were examined in these 12 SNPs. We detected one novel genome-wide significant interaction associated with LS-BMD at the Chr3p26.1-p25.1 locus, near the GRM7 gene (male effect?=?0.02 and p?=?3.0?X?10-5; female effect?=?-0.007 and p?=?3.3?X?10-2), and 11 suggestive loci associated with either FN- or LS-BMD in discovery cohorts. However, there was no evidence for genome-wide significant (p?<?5?X?10-8) gene-by-sex interaction in the joint analysis of discovery and replication cohorts. Despite the large collaborative effort, no genome-wide significant evidence for gene-by-sex interaction was found to influence BMD variation in this screen of autosomal markers. If they exist, gene-by-sex interactions for BMD probably have weak effects, accounting for less than 0.08% of the variation in these traits per implicated SNP. (c) 2012 American Society for Bone and Mineral Research. | en |
dc.source.uri | <Go to ISI>://WOS:000308925800003 | |
dc.subject | GENE-BY-SEX INTERACTION | en |
dc.subject | BMD | en |
dc.subject | ASSOCIATION | en |
dc.subject | AGING | en |
dc.subject | GENOME-WIDE ASSOCIATION | en |
dc.subject | QUANTITATIVE TRAIT LOCI | en |
dc.subject | GENOTYPE IMPUTATION | en |
dc.subject | GENDER | en |
dc.subject | MASS | en |
dc.subject | OSTEOPOROSIS | en |
dc.subject | CELLS | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | DETERMINANTS | en |
dc.subject | Endocrinology & Metabolism | en |
dc.title | Assessment of gene-by-sex interaction effect on bone mineral density | en |
dc.type | journalArticle | en |
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