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Bacterial live vaccines with graded level of attenuation achieved by antibiotic resistance mutations: transduction experiments on the functional unit of resistance, attenuation and further accompanying markers
dc.creator | Linde, K. | en |
dc.creator | Fthenakis, G. C. | en |
dc.creator | Fichtner, A. | en |
dc.date.accessioned | 2015-11-23T10:38:03Z | |
dc.date.available | 2015-11-23T10:38:03Z | |
dc.date.issued | 1998 | |
dc.identifier | 10.1016/s0378-1135(98)00201-6 | |
dc.identifier.issn | 0378-1135 | |
dc.identifier.uri | http://hdl.handle.net/11615/30368 | |
dc.description.abstract | At least 10% of spontaneous chromosomal antibiotic resistant mutants of bacteria express a strain-dependent graded reduction of virulence; this correlates linearly with a prolonged generation time. Occasionally, these mutants are temperature sensitive or/and auxotrophe. The work described in this paper provides evidence that in such strains the resistance and the accompanying markers exist only as a functional genetic unit. In a series of transduction experiments with a pathogenic strain of Salmonella typhimurium, it was found that without exception, the resistance and the additional markers were 100% simultaneously transferred. Furthermore, antibiotic-resistant Escherichia coli mutants with prolonged generation time, were isolated from faecal samples; it is thus indicated that, such innocuous mutants occur at any time in the intestine. It is concluded that concerns connecting such mutants to the possibility of resistance dissemination are unfounded; furthermore, even if transfer of resistance occurred, only attenuated strains would be disseminated. (C) 1998 Elsevier Science B.V. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000074915200004 | |
dc.subject | antibiotic resistance | en |
dc.subject | attenuation | en |
dc.subject | transduction | en |
dc.subject | vaccination | en |
dc.subject | SHIGELLA-FLEXNERI 2A | en |
dc.subject | SONNEI-I-VACCINE | en |
dc.subject | ESCHERICHIA-COLI | en |
dc.subject | QUINOLONE | en |
dc.subject | RESISTANCE | en |
dc.subject | CANDIDATE STRAINS | en |
dc.subject | GYRA MUTATIONS | en |
dc.subject | IDENTIFICATION | en |
dc.subject | PROTEIN | en |
dc.subject | Microbiology | en |
dc.subject | Veterinary Sciences | en |
dc.title | Bacterial live vaccines with graded level of attenuation achieved by antibiotic resistance mutations: transduction experiments on the functional unit of resistance, attenuation and further accompanying markers | en |
dc.type | journalArticle | en |
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