dc.creator | Liadaki, K. | en |
dc.creator | Casar, J. C. | en |
dc.creator | Wessen, M. | en |
dc.creator | Luth, E. S. | en |
dc.creator | Jun, S. | en |
dc.creator | Gussoni, E. | en |
dc.creator | Kunkel, L. M. | en |
dc.date.accessioned | 2015-11-23T10:37:43Z | |
dc.date.available | 2015-11-23T10:37:43Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1369/0022155411428991 | |
dc.identifier.issn | 0022-1554 | |
dc.identifier.uri | http://hdl.handle.net/11615/30281 | |
dc.description.abstract | Skeletal muscle growth and its regeneration following injury rely on myogenic progenitor cells, a heterogeneous population that includes the satellite cells and other interstitial progenitors. The present study demonstrates that surface expression of beta 4 integrin marks a population of vessel-associated interstitial muscle progenitor cells. Muscle beta 4 integrin-positive cells do not express myogenic markers upon isolation. However, they are capable of undergoing myogenic specification in vitro and in vivo: beta 4 integrin cells differentiate into multinucleated myotubes in culture dishes and contribute to muscle regeneration upon delivery into diseased mice. Subfractionation of beta 4 integrin-expressing cells based on CD31 expression does not further enrich for myogenic precursors. These findings support the expression of beta 4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. (J Histochem Cytochem 60:31-44, 2012) | en |
dc.source.uri | <Go to ISI>://WOS:000298603800003 | |
dc.subject | beta 4 integrin | en |
dc.subject | skeletal muscle | en |
dc.subject | progenitor cells | en |
dc.subject | SIDE-POPULATION CELLS | en |
dc.subject | DUCHENNE MUSCULAR-DYSTROPHY | en |
dc.subject | STEM-CELLS | en |
dc.subject | SATELLITE CELLS | en |
dc.subject | SELF-RENEWAL | en |
dc.subject | ALPHA-6-BETA-4 INTEGRIN | en |
dc.subject | CYTOPLASMIC | en |
dc.subject | DOMAINS | en |
dc.subject | GENETIC ANALYSES | en |
dc.subject | CARCINOMA-CELLS | en |
dc.subject | DORSAL AORTA | en |
dc.subject | Cell Biology | en |
dc.title | beta 4 Integrin Marks Interstitial Myogenic Progenitor Cells in Adult Murine Skeletal Muscle | en |
dc.type | journalArticle | en |