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Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event
dc.creator | Levisianou, D. | en |
dc.creator | Foussas, S. | en |
dc.creator | Skopelitis, E. | en |
dc.creator | Adamopoulou, E. | en |
dc.creator | Xenopoulou, T. | en |
dc.creator | Destounis, A. | en |
dc.creator | Koukoulis, G. | en |
dc.creator | Skoularigis, I. | en |
dc.creator | Melidonis, A. | en |
dc.creator | Triposkiadis, F. | en |
dc.date.accessioned | 2015-11-23T10:37:41Z | |
dc.date.available | 2015-11-23T10:37:41Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1016/j.diabres.2012.11.023 | |
dc.identifier.issn | 0168-8227 | |
dc.identifier.uri | http://hdl.handle.net/11615/30269 | |
dc.description.abstract | Objectives: to investigate the predictive value of arterial stiffness (AS) estimation for long-term recurrences in patients with type 2 diabetes (DM2) following acute coronary event. Patients and methods: prospective observational study involving 119 DM2 patients without history of coronary heart disease admitted with ST-segment elevation myocardial infarction (STEMI). Medical history, anthropometrics, smoking, HbA1c, lipid profile, troponine-I levels, and left ventricular ejection fraction (LVEF) were recorded. Carotid-femoral pulse wave velocity (cf-PWV) was measured 1 month after discharge. Patients were followed up for 36 months or to reach an end-point: cardiovascular death, acute coronary event, angioplasty or hospitalization for acute heart failure. To facilitate analysis, patients were divided into two groups according to cf-PWV, using the accepted cut-off value of 12 m/s. Results: overall, 34 patients had a recurrence. In Kaplan-Meier analysis patients with cf-PWV > 12 m/s had mean time-to-event 353 +/- 43 days compared to 505 +/- 115 days for patients with cf-PWV <= 12 m/s, log rank = 0.0252. In multivariate analysis factors independently associated with recurrence were age (66.53 +/- 6.87 vs. 61.54 +/- 10.77 years, p = 0.015), LVEF (41.66 +/- 8.21 vs. 47.58 +/- 8.11%, p = 0.001) and cf-PWV (13.94 +/- 2.91 vs. 12.35 +/- 2.77 m/s, p = 0.008). Conclusions: AS estimation in patients with DM2 after STEMI discriminate patients at higher risk for 3-year recurrence, and maybe valuable for distinguishing patients likely to require a more rigorous therapeutic intervention. (C) 2012 Elsevier Ireland Ltd. All rights reserved. | en |
dc.source.uri | <Go to ISI>://WOS:000317278700013 | |
dc.subject | Arterial stiffness | en |
dc.subject | Pulse wave velocity | en |
dc.subject | Recurent acute coronary | en |
dc.subject | syndrome | en |
dc.subject | PULSE-WAVE VELOCITY | en |
dc.subject | STAGE RENAL-DISEASE | en |
dc.subject | AORTIC STIFFNESS | en |
dc.subject | CARDIOVASCULAR MORTALITY | en |
dc.subject | INDEPENDENT PREDICTOR | en |
dc.subject | HYPERTENSIVE PATIENTS | en |
dc.subject | HEART-DISEASE | en |
dc.subject | CLINICAL-APPLICATIONS | en |
dc.subject | CARDIAC-HYPERTROPHY | en |
dc.subject | TASK-FORCE | en |
dc.subject | Endocrinology & Metabolism | en |
dc.title | Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event | en |
dc.type | journalArticle | en |
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