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Accelerated Hypofractionated Whole-Breast Irradiation With Concomitant Daily Boost in Early Breast Cancer
dc.creator | Kyrgias, G. | en |
dc.creator | Zygogianni, A. | en |
dc.creator | Theodorou, K. | en |
dc.creator | Koukourakis, M. | en |
dc.creator | Oikonomou, A. | en |
dc.creator | Kouvaris, J. | en |
dc.creator | Kouloulias, V. | en |
dc.date.accessioned | 2015-11-23T10:37:13Z | |
dc.date.available | 2015-11-23T10:37:13Z | |
dc.date.issued | 2015 | |
dc.identifier | 10.1097/COC.0b013e3182a46740 | |
dc.identifier.issn | 0277-3732 | |
dc.identifier.uri | http://hdl.handle.net/11615/30091 | |
dc.description.abstract | Objectives:The aim of this study is to evaluate the feasibility and the related toxicity of hypofractionated whole-breast irradiation with a concomitant daily boost in early breast cancer women not eligible for accelerated partial-breast irradiation.Methods:Twenty-seven patients received 46 Gy to the whole breast in 20 fractions/4 weeks with 2.3 Gy/fraction plus an additional concomitant daily boost of 0.4 Gy to the tumor bed, giving a total dose of 54 Gy (EQD(2)=60 Gy). The cosmetic outcome was assessed according to the European Organization for Research and Treatment of Cancer and Radiation Therapy Oncology Group grading system.Results:Three months after the end of radiotherapy, 59.2% and 40.7% of patients showed grade 0 skin toxicity and grade 1 skin toxicity, respectively. After 6 months, 70.4% and 29.6% of patients showed grade 0 and grade 1 skin toxicity. After 1 year, grade 0 skin toxicity was found in 77.7% of the patients and grade 1 skin toxicity in 22.2% of the patients. After 18 months, grade 0 skin toxicity was found in 92.6% and grade 1 skin toxicity in 7.4% of the patients. After a median follow-up of 24 months, all patients showed excellent cosmetic results with minimal breast edema and minimal skin changes. There have been no local relapses to date.Conclusion:The accelerated hypofractionated schedule with a concomitant boost appears to be an acceptable alternative to the traditional longer schedule, with low local toxicity and excellent to good short-term cosmetic results, although a much longer follow-up is needed to assess the local control rate. | en |
dc.source | American Journal of Clinical Oncology-Cancer Clinical Trials | en |
dc.source.uri | <Go to ISI>://WOS:000359835200006 | |
dc.subject | hypofractionation | en |
dc.subject | breast cancer | en |
dc.subject | concomitant boost | en |
dc.subject | toxicity | en |
dc.subject | MODULATED RADIATION-THERAPY | en |
dc.subject | RANDOMIZED-TRIAL | en |
dc.subject | CONSERVING TREATMENT | en |
dc.subject | LOCAL-CONTROL | en |
dc.subject | RADIOTHERAPY HYPOFRACTIONATION | en |
dc.subject | INCORPORATED BOOST | en |
dc.subject | UK | en |
dc.subject | STANDARDIZATION | en |
dc.subject | ELECTRON BOOST | en |
dc.subject | FRACTIONATION | en |
dc.subject | TOXICITY | en |
dc.subject | Oncology | en |
dc.title | Accelerated Hypofractionated Whole-Breast Irradiation With Concomitant Daily Boost in Early Breast Cancer | en |
dc.type | journalArticle | en |
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