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dc.creatorKyrgias, G.en
dc.creatorZygogianni, A.en
dc.creatorTheodorou, K.en
dc.creatorKoukourakis, M.en
dc.creatorOikonomou, A.en
dc.creatorKouvaris, J.en
dc.creatorKouloulias, V.en
dc.date.accessioned2015-11-23T10:37:13Z
dc.date.available2015-11-23T10:37:13Z
dc.date.issued2015
dc.identifier10.1097/COC.0b013e3182a46740
dc.identifier.issn0277-3732
dc.identifier.urihttp://hdl.handle.net/11615/30091
dc.description.abstractObjectives:The aim of this study is to evaluate the feasibility and the related toxicity of hypofractionated whole-breast irradiation with a concomitant daily boost in early breast cancer women not eligible for accelerated partial-breast irradiation.Methods:Twenty-seven patients received 46 Gy to the whole breast in 20 fractions/4 weeks with 2.3 Gy/fraction plus an additional concomitant daily boost of 0.4 Gy to the tumor bed, giving a total dose of 54 Gy (EQD(2)=60 Gy). The cosmetic outcome was assessed according to the European Organization for Research and Treatment of Cancer and Radiation Therapy Oncology Group grading system.Results:Three months after the end of radiotherapy, 59.2% and 40.7% of patients showed grade 0 skin toxicity and grade 1 skin toxicity, respectively. After 6 months, 70.4% and 29.6% of patients showed grade 0 and grade 1 skin toxicity. After 1 year, grade 0 skin toxicity was found in 77.7% of the patients and grade 1 skin toxicity in 22.2% of the patients. After 18 months, grade 0 skin toxicity was found in 92.6% and grade 1 skin toxicity in 7.4% of the patients. After a median follow-up of 24 months, all patients showed excellent cosmetic results with minimal breast edema and minimal skin changes. There have been no local relapses to date.Conclusion:The accelerated hypofractionated schedule with a concomitant boost appears to be an acceptable alternative to the traditional longer schedule, with low local toxicity and excellent to good short-term cosmetic results, although a much longer follow-up is needed to assess the local control rate.en
dc.sourceAmerican Journal of Clinical Oncology-Cancer Clinical Trialsen
dc.source.uri<Go to ISI>://WOS:000359835200006
dc.subjecthypofractionationen
dc.subjectbreast canceren
dc.subjectconcomitant boosten
dc.subjecttoxicityen
dc.subjectMODULATED RADIATION-THERAPYen
dc.subjectRANDOMIZED-TRIALen
dc.subjectCONSERVING TREATMENTen
dc.subjectLOCAL-CONTROLen
dc.subjectRADIOTHERAPY HYPOFRACTIONATIONen
dc.subjectINCORPORATED BOOSTen
dc.subjectUKen
dc.subjectSTANDARDIZATIONen
dc.subjectELECTRON BOOSTen
dc.subjectFRACTIONATIONen
dc.subjectTOXICITYen
dc.subjectOncologyen
dc.titleAccelerated Hypofractionated Whole-Breast Irradiation With Concomitant Daily Boost in Early Breast Canceren
dc.typejournalArticleen


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