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Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease
dc.creator | Koutroumpas, A. | en |
dc.creator | Ziogas, A. | en |
dc.creator | Alexiou, I. | en |
dc.creator | Barouta, G. | en |
dc.creator | Sakkas, L. I. | en |
dc.date.accessioned | 2015-11-23T10:36:39Z | |
dc.date.available | 2015-11-23T10:36:39Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1007/s10067-010-1498-z | |
dc.identifier.issn | 0770-3198 | |
dc.identifier.uri | http://hdl.handle.net/11615/29939 | |
dc.description.abstract | This study aimed to assess the effect of mofetil mycophenolate (MMF), an inhibitor of lymphocyte proliferation, on lung function and skin in patients with systemic sclerosis (SSc)-associated interstitial lung disease (SSc-ILD). In this retrospective study, we reviewed the medical files of 10 patients with SSc-ILD (eight females, 10 patients with diffuse SSc; mean age, 59.7 +/- 12.7 years; disease duration, 7.7 +/- 4.7 years). Patients were treated with MMF (2 g/day) for 12 months. Lung function tests and the modified Rodnan total skin score (mRTSS) were assessed at baseline and at 12 months. Results were analyzed by paired Student's t test. There was a significant increase in forced vital capacity and a nonsignificant increase in carbon monoxide diffusing capacity at 12 months in patients on MMF (p = 0.04 and 0.66, respectively). There was no effect on mRTSS. MMF stabilizes lung function of SSc-ILD after 12 months of treatment. | en |
dc.source | Clinical Rheumatology | en |
dc.source.uri | <Go to ISI>://WOS:000281392000014 | |
dc.subject | Interstitial lung disease | en |
dc.subject | Mycophenolate mofetil | en |
dc.subject | Systemic sclerosis | en |
dc.subject | CYCLOPHOSPHAMIDE | en |
dc.subject | IMATINIB | en |
dc.subject | Rheumatology | en |
dc.title | Mycophenolate mofetil in systemic sclerosis-associated interstitial lung disease | en |
dc.type | journalArticle | en |
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