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Treatment of Low-risk Prostate Cancer with Radical Hypofractionated Accelerated Radiotherapy with Cytoprotection (HypoARC): An Interim Analysis of Toxicity and Efficacy
dc.creator | Koukourakis, M. I. | en |
dc.creator | Kyrgias, G. | en |
dc.creator | Papadopoulou, A. | en |
dc.creator | Panteliadou, M. | en |
dc.creator | Giatromanolaki, A. | en |
dc.creator | Sivridis, E. | en |
dc.creator | Mavropoulou, S. | en |
dc.creator | Kalogeris, K. | en |
dc.creator | Nassos, P. | en |
dc.creator | Milioudis, N. | en |
dc.creator | Touloupidis, S. | en |
dc.date.accessioned | 2015-11-23T10:36:04Z | |
dc.date.available | 2015-11-23T10:36:04Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.uri | http://hdl.handle.net/11615/29771 | |
dc.description.abstract | Aim: Radiobiological analysis of clinical data suggests that prostate cancer has a low alpha/beta ratio, implying that large radiotherapy fractions may better control the disease. Acceleration of radiotherapy may be also of importance in a subset of tumors. In this study we assessed the feasibility and efficacy of a highly accelerated and hypofractionated scheme of radiotherapy (HypoARC), for the treatment of localized low risk prostate cancer. Patients and Methods: Fifty-five patients with prostate cancer (T1-2 stage, Gleason score <7 and prostate specific antigen (PSA) <10 ng/ml) were treated with localized conformal 4-field radiotherapy to the prostate and seminal vesicles: 51 Gy were delivered (3.4 Gylfraction, within 19 days). The biological dose to the prostate ranged from 67.9-91.7 Gy. Amifostine (0-1000 mg depending upon tolerance) was delivered daily for cytoprotection. The median follow-up of patients is 30 (6-69) months. Results: Early toxicity was overall low, proctitis being the most frequent side-effect (23.6% grade II). High dose amifostine significantly protected against proctitis (p=0.005). Grade 2 frequency and dysurea occurred in 1.8% and 3.7% of cases, respectively. There was no late toxicity >= grade 2. Amifostine significantly protected against chronic frequency (p=0.02). Within a median follow-up of 30 months, one patient (1.8%) experienced a biochemical relapse. Conclusion: HypoARC is feasible and safe for patients with low-risk prostate cancer and, considering also the high efficacy noted, a strong rationale is provided for the further evaluation of HypoARC in randomized trials. | en |
dc.source | Anticancer Research | en |
dc.source.uri | <Go to ISI>://WOS:000291235300031 | |
dc.subject | Prostate cancer | en |
dc.subject | radiotherapy | en |
dc.subject | hypofractionation | en |
dc.subject | acceleration | en |
dc.subject | amifostine | en |
dc.subject | cytoprotection | en |
dc.subject | LOW ALPHA/BETA-RATIO | en |
dc.subject | RANDOMIZED-TRIAL | en |
dc.subject | NORMAL TISSUE | en |
dc.subject | FRACTIONATION | en |
dc.subject | KI-67 | en |
dc.subject | EXPERIENCE | en |
dc.subject | CARCINOMA | en |
dc.subject | TUMORS | en |
dc.subject | ADENOCARCINOMA | en |
dc.subject | PROLIFERATION | en |
dc.subject | Oncology | en |
dc.title | Treatment of Low-risk Prostate Cancer with Radical Hypofractionated Accelerated Radiotherapy with Cytoprotection (HypoARC): An Interim Analysis of Toxicity and Efficacy | en |
dc.type | journalArticle | en |
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