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Molecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemia

dc.creatorKollia, P.en
dc.creatorSamara, M.en
dc.creatorStamatopoulos, K.en
dc.creatorBelessi, C.en
dc.creatorStavroyianni, N.en
dc.creatorTsompanakou, A.en
dc.creatorAthanasiadou, A.en
dc.creatorVainvakopoulos, N.en
dc.creatorLaoutaris, N.en
dc.creatorAnagnostopoulos, A.en
dc.creatorFassas, A.en
dc.date.accessioned2015-11-23T10:35:14Z
dc.date.available2015-11-23T10:35:14Z
dc.date.issued2003
dc.identifier10.1016/s0145-2126(03)00100-0
dc.identifier.issn0145-2126
dc.identifier.urihttp://hdl.handle.net/11615/29535
dc.description.abstractWe examined transferrin receptor (TfR) 1 and TfR2 mRNA expression in 50 acute myeloid leukemia (AML) patients by RT-PCR, with primers specific for exons 15-17 (TfR1), 3-5 (TfR2-alpha) and 4-5 (TfR2-beta) of the corresponding gene. There were 4/50 TfR1-negative (-), 3/50 TfR2-alpha mRNA (-) and 13/50 TfR2-beta mRNA (-) cases; only three cases were TfR1/2 mRNA (-). No significant correlations were identified between TfR2-beta mRNA negativity and specific FAB subtypes, karyotype or attainment of complete remission. These findings suggest that: (i) TfR2 expression is not restricted to erythroid cells, and (ii) iron import proteins might complement each other in AML cells. (C) 2003 Elsevier Ltd. All rights reserved.en
dc.source.uri<Go to ISI>://WOS:000185431400007
dc.subjectacute myeloid leukemiaen
dc.subjecttransferrin receptoren
dc.subjectCELLSen
dc.subjectIRONen
dc.subjectOncologyen
dc.subjectHematologyen
dc.titleMolecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemiaen
dc.typejournalArticleen


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