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Steroid hormones polymorphisms and cholelithiasis in Greek population
dc.creator | Kitsiou-Tzeli, S. | en |
dc.creator | Giannatou, E. | en |
dc.creator | Spanos, I. | en |
dc.creator | Nicolaidou, P. | en |
dc.creator | Fretzayas, A. | en |
dc.creator | Tzetis, M. | en |
dc.creator | Lazaris, D. | en |
dc.creator | Kanavakis, E. | en |
dc.creator | Tsezou, A. | en |
dc.date.accessioned | 2015-11-23T10:34:57Z | |
dc.date.available | 2015-11-23T10:34:57Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.1111/j.1478-3231.2006.01385.x | |
dc.identifier.issn | 1478-3223 | |
dc.identifier.uri | http://hdl.handle.net/11615/29447 | |
dc.description.abstract | Background: Genetic variation in genes involved in steroid biosynthesis, metabolism and signal transduction have been suggested to play a role in gallstone disease. Methods: To elucidate the possible role of genetic variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta) and androgen receptor (AR) genes in breast cancer risk, the -1174(TA)(n), c.1092+3607(CA)(n) and c.172(CAG)(n) repeat polymorphisms of the three genes were studied. A case-control cohort of 99 patients with cholelithiasis and 179 controls were used. Results: No significant difference was observed in the frequency distribution of -1174(TA)(0-26) in the ER-alpha gene between patients and controls, while a significant difference was observed in the frequency distribution of repeat polymorphism c.1092+3607(CA)(5-27) and c.172(CAG)(5-32) in the ER-beta gene and AR gene, respectively (P <= 0.0001 and P=0.05, respectively). A significant difference was observed in the repeat genotype distribution (SS, SL, LL) in the (CA)(n) of the ER-beta gene (P < 0.0001) and in the (CAG)(n) of the AR gene (P <= 0.0001). A significantly decreased odds ratio for cholelithiasis risk was observed in individuals having the SL and LL genotype for ER-beta gene compared with SS genotype (OR=0.212; 95% CI 0.105-0.426; P < 0.0001 and OR=0.042; 95% CI 0.018-0.097, respectively) and LL genotype for AR gene (OR=0.622; 95% CI 0.345-1.121; P=0.114 and OR=0.287; 95% CI 0.151-0.543, P < 0.0001, respectively). This protective effect of SL and LL genotypes for ER-beta and LL for AR gene remained evident (P < 0.0001 for all of them) even after adjustment for various risk factors. Conclusions: In conclusion an association for cholelithiasis risk between short alleles for both c.1092+3607(CA)(5-27) and c.172(CAG)(5-32) repeat polymorphisms of the ER-beta and AR was found in individuals of Greek descent. | en |
dc.source.uri | <Go to ISI>://WOS:000243534600009 | |
dc.subject | cholelithiasis | en |
dc.subject | estrogen | en |
dc.subject | androgen receptors | en |
dc.subject | repeat polymorphisms | en |
dc.subject | steroid hormones | en |
dc.subject | ESTROGEN-RECEPTOR-ALPHA | en |
dc.subject | PROSTATE-CANCER RISK | en |
dc.subject | ANDROGEN RECEPTOR | en |
dc.subject | GALLSTONE DISEASE | en |
dc.subject | BETA-GENE | en |
dc.subject | ASSOCIATION | en |
dc.subject | REPEAT | en |
dc.subject | LENGTH | en |
dc.subject | FORMS | en |
dc.subject | WOMEN | en |
dc.subject | Gastroenterology & Hepatology | en |
dc.title | Steroid hormones polymorphisms and cholelithiasis in Greek population | en |
dc.type | journalArticle | en |
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