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Vascular endothelial growth factor (VEGF) in pleural effusions
dc.creator | Kiropoulos, T. S. | en |
dc.creator | Daniil, Z. | en |
dc.creator | Gourgoulianis, K. I. | en |
dc.creator | Zakynthinos, E. | en |
dc.date.accessioned | 2015-11-23T10:34:54Z | |
dc.date.available | 2015-11-23T10:34:54Z | |
dc.date.issued | 2007 | |
dc.identifier | 10.2174/157340807781369056 | |
dc.identifier.issn | 15734080 | |
dc.identifier.uri | http://hdl.handle.net/11615/29434 | |
dc.description.abstract | Pleural effusion is a common clinical problem in everyday clinical practice. Vascular endothelial growth factor (VEGF) is a 34-45 kDa homodimeric glycoprotein, which is a potent mediator of angiogenesis and vascular permeability. VEGF is present in significant quantities in pleural effusions of different origins, and its levels are consistently higher in exudates than in transudates. There is compelling experimental evidence demonstrating that VEGF is a crucial mediator in fluid formation. In the pleural space mesothelial cells are likely the principal source of fluid VEGF. It is also produced by most malignant cell types and inflammatory cells including lymphocytes, eosinophils, macrophages, and neutrophls. VEGF production can be stimulated by various cytokines, among which transforming growth factor beta (TGF-β) appears to be the most potent and consistent. Hypoxia and ischemia are the most established physical stimulators of VEGF. Promising results are rapidly accumulating on the use of VEGF inhibition in preventing pleural fluid accumulation; clinical trials are underway using VEGF antagonists in the management of malignant pleural effusions. The main focus of this review is to evaluate the role of VEGF in the pathogenesis and differential diagnosis of pleural effusions as well as the therapeutic implications of VEGF in control of effusions formation. © 2007 Bentham Science Publishers Ltd. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-34547768037&partnerID=40&md5=8b6cc4ce638b4ee5a8aa5f45fab70603 | |
dc.subject | Angiogenesis | en |
dc.subject | Empyema | en |
dc.subject | Hypoxia | en |
dc.subject | Pleural effusion | en |
dc.subject | Staphylococcus aureus | en |
dc.subject | Transforming growth factor | en |
dc.subject | Tuberculosis | en |
dc.subject | Tyrosine-kinase receptors | en |
dc.subject | Vascular endothelial growth factor | en |
dc.subject | catechin | en |
dc.subject | corticosteroid | en |
dc.subject | cyclooxygenase 2 inhibitor | en |
dc.subject | cytokine | en |
dc.subject | glycoprotein | en |
dc.subject | homodimer | en |
dc.subject | interferon | en |
dc.subject | monoclonal antibody | en |
dc.subject | neutralizing antibody | en |
dc.subject | neutralizing antibody A4.6.1 | en |
dc.subject | octreotide | en |
dc.subject | perindopril | en |
dc.subject | protein tyrosine kinase inhibitor | en |
dc.subject | transforming growth factor beta | en |
dc.subject | transforming growth factor beta antibody | en |
dc.subject | unclassified drug | en |
dc.subject | vasculotropin | en |
dc.subject | vasculotropin antibody | en |
dc.subject | vasculotropin inhibitor | en |
dc.subject | vasculotropin receptor | en |
dc.subject | vasculotropin receptor 2 antibody | en |
dc.subject | blood vessel permeability | en |
dc.subject | cancer cell | en |
dc.subject | cell type | en |
dc.subject | clinical practice | en |
dc.subject | clinical trial | en |
dc.subject | differential diagnosis | en |
dc.subject | disease control | en |
dc.subject | drug activity | en |
dc.subject | eosinophil | en |
dc.subject | exudate | en |
dc.subject | gene therapy | en |
dc.subject | human | en |
dc.subject | inflammatory cell | en |
dc.subject | ischemia | en |
dc.subject | lymphocyte | en |
dc.subject | macrophage | en |
dc.subject | mesothelium cell | en |
dc.subject | neutrophil | en |
dc.subject | nonhuman | en |
dc.subject | pleura effusion | en |
dc.subject | pleura fluid | en |
dc.subject | protein function | en |
dc.subject | protein targeting | en |
dc.subject | review | en |
dc.title | Vascular endothelial growth factor (VEGF) in pleural effusions | en |
dc.type | journalArticle | en |
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